merck millipore,默克密理愽
  • merck millipore,默克密理博,09-433,Anti-phospho-IRS1 (Tyr628) mouse/ (Tyr632) human Antibody

  • merck millipore,默克密理博,09-433,Anti-phospho-IRS1 (Tyr628) mouse/ (Tyr632) human Antibody

    产品名称：Anti-phospho-IRS1 (Tyr628) mouse/ (Tyr632) human Antibody
    产品型号：09-433
    Anti-phospho-IRS1 (Tyr628) mouse/ (Tyr632) human Antibody is an antibody against phospho-IRS1 (Tyr628) mouse/ (Tyr632) human for use in WB.

    merck millipore,默克密理博,09-433,Anti-phospho-IRS1 (Tyr628) mouse/ (Tyr632) human Antibody

  • 产品介绍
  • merck millipore,默克密理博,09-433,Anti-phospho-IRS1 (Tyr628) mouse/ (Tyr632) human Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 09-433
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-IRS1 (Tyr628) mouse/ (Tyr632) human Antibody
    Alternate Names
    • Insulin Receptor Substrate 1
    • HIRS-1
    背景信息 Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a central role in maintaining basic cellular functions such as growth, survival, and metabolism. They act as docking proteins between the insulin receptor and a complex network of intracellular signaling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified that differ as to tissue distribution, subcellular localization, developmental expression, binding to the insulin receptor, and interaction with SH2 domain-containing proteins. Results from targeted disruption of the IRS genes in mice have provided important clues to the functional differences among these related molecules, suggesting they play different and specific roles in vivo. The available data are consistent with the notion that IRS-1 and IRS-2 are not functionally interchangeable in tissues that are responsible for glucose production (liver), glucose uptake (skeletal muscle and adipose tissue), and insulin production (pancreatic β cells). In fact, IRS-1 appears to have its major role in skeletal muscle whereas IRS-2 appears to regulate hepatic insulin action as well as pancreatic β cell development and survival. By contrast, IRS-3 and IRS-4 genes appear to play a redundant role in the IRS signaling system. Defects in muscle IRS-1 expression and function have been reported in insulin-resistant states such as obesity and type 2 diabetes.
    产品信息
    格式 Purified
    演示 Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol.
    应用
    应用 Anti-phospho-IRS1 (Tyr628) mouse/ (Tyr632) human Antibody is an antibody against phospho-IRS1 (Tyr628) mouse/ (Tyr632) human for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide corresponding to amino acids encompassing and including phosphorylated Tyr628 in mouse and Tyr632 in human of IRS1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes phospho-IRS1 (Tyr628) mouse/ (Tyr632) human
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note Tested on human. Predicted to cross react with mouse and rat based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_005544 (Human)
    基因符号
    • HIRS-1
    • IRS1
    • IRS-1
    修改
    • Phosphorylation
    纯化方法 Affinity Purfied
    UniProt编号
    • P35568
    UniProt汇总 FUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
    SIZE: 1242 amino acids; 131591 Da
    SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7.
    PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].
    SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain.
    产品使用声明
    质量保证 routinely evaluated by western blot on lysates from untreated and insulin-treated (30 minutes) HEK 293 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,09-433,Anti-phospho-IRS1 (Tyr628) mouse/ (Tyr632) human Antibody

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