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描述 产品目录编号 14-684M 品牌系列 Upstate
商名 - Upstate
描述 IRAK1 Protein, active, 250 µg 概述 N-terminal 6His-tagged, recombinant, human IRAK1 amino acids 194-end. 应用 应用 Active, N-terminal 6His-tagged, recombinant, human IRAK1 amino acids 194-end. For use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 Human IRAK1 expressed by baculovirus in Sf21 cells. 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_001025242.1
- NM_001025243.1
- NM_001569.3
Entrez基因汇总 This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. 基因符号 - pelle
- IRAK1
- IRAK
- IRAK-1
蛋白靶 IRAK1 纯化方法 Ni2+/NTA-agarose 靶子系列 TKL UniProt编号 - P51617
UniProt汇总 FUNCTION: SwissProt: P51617 # Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.
COFACTOR: Magnesium.
SIZE: 712 amino acids; 76537 Da
SUBUNIT: IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1.
TISSUE SPECIFICITY: Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.
PTM: Autophosphorylated or is transphosphorylated by IRAK4 following recruitment to the IL-1RI. In the case of isoform 1, this is linked to ubiquitination and degradation.
SIMILARITY: SwissProt: P51617 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of MBP (13-104). 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C from date of shipment 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-684) and in bulk (cat# 14-684-K).
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