merck millipore,默克密理愽
  • merck millipore,默克密理博,14-659,LIM Kinase 1 Protein, unactive, 50 µg

  • merck millipore,默克密理博,14-659,LIM Kinase 1 Protein, unactive, 50 µg

    产品名称：LIM Kinase 1 Protein, unactive, 50 µg
    产品型号：14-659
    Unactive, N-terminal 6His-tagged, recombinant, human LIM Kinase 1, amino acids 285-638. For use in Kinase Assays.

    merck millipore,默克密理博,14-659,LIM Kinase 1 Protein, unactive, 50 µg

  • 产品介绍
  • merck millipore,默克密理博,14-659,LIM Kinase 1 Protein, unactive, 50 µg

    描述
    产品目录编号 14-659
    品牌系列 Upstate
    商名
    • Upstate
    描述 LIM Kinase 1 Protein, unactive, 50 µg
    概述 N-terminal 6His-tagged, recombinant, human LIM Kinase 1, amino acids 285-638.
    应用
    应用 Unactive, N-terminal 6His-tagged, recombinant, human LIM Kinase 1, amino acids 285-638. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 cells.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002314.2
    Entrez基因汇总 There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.
    基因符号
    • LIMK-1
    • LIMK1
    • LIMK
    蛋白靶 LIMK1
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TKL
    UniProt编号
    • P53667
    UniProt汇总 FUNCTION: SwissProt: P53667 # Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. May be involved in brain development.
    SIZE: 647 amino acids; 72585 Da
    SUBUNIT: Self-associates. The LIM domain interacts with the cytoplasmic domain of NRG1. Binds ROCK1. Interacts with SSH1.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.
    PTM: Autophosphorylated (By similarity). & Phosphorylated on serine and/or threonine residues by ROCK1. May be dephosphorylated and inactivated by SSH1.
    DISEASE: SwissProt: P53667 # Haploinsufficiency of LIMK1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.
    SIMILARITY: SwissProt: P53667 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 2 LIM zinc-binding domains. & Contains 1 PDZ (DHR) domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of Cofilin 1 (Catalog # 12-556).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C from date of shipment
    包装信息
    数量 50 µg

    merck millipore,默克密理博,14-659,LIM Kinase 1 Protein, unactive, 50 µg

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