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描述 产品目录编号 14-652 品牌系列 Upstate
商名 - Upstate
描述 SIK Protein, active, 10 µg 概述 N-terminal 6His-tagged, recombinant, human SIK, amino acids 1-281. 应用 应用 Active, N-terminal 6His-tagged, recombinant, human SIK, amino acids 1-281. For use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 Expressed by baculovirus in Sf21 insect cells. 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_173354.3
基因符号 - SIK1
- SNF1LK
- MSK
- msk
- SIK
蛋白靶 SIK 纯化方法 Ni2+/NTA-agarose 靶子系列 CAMK UniProt编号 - P57059
UniProt汇总 FUNCTION: SwissProt: P57059 # Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3 (By similarity).
COFACTOR: Magnesium.
SIZE: 783 amino acids; 84902 Da
SUBUNIT: Binds to and is activated by YWHAZ when phosphorylated on Thr-182.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: P57059 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. & Contains 1 protein kinase domain. & Contains 1 UBA domain.产品使用声明 质量保证 Routinely evaluated by phosphorylation of AMARA Substrate Peptide (Catalog# 12-557). 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 6 months at -70°C from date of shipment 包装信息 数量 10 µg
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