merck millipore,默克密理愽
  • merck millipore,默克密理博,14-601,ROKβ/ROCK-I Protein, active, 10 µg

  • merck millipore,默克密理博,14-601,ROKβ/ROCK-I Protein, active, 10 µg

    产品名称：ROKβ/ROCK-I Protein, active, 10 µg
    产品型号：14-601
    Active, N-terminal His6-tagged, recombinant, human ROCK-I amino acids 17-535, autoactivated by incubating with Mg/ATP & redialysed to remove excess ATP. For use in Kinase Assays.

    merck millipore,默克密理博,14-601,ROKβ/ROCK-I Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-601,ROKβ/ROCK-I Protein, active, 10 µg

    描述
    产品目录编号 14-601
    品牌系列 Upstate
    商名
    • Upstate
    描述 ROKβ/ROCK-I Protein, active, 10 µg
    概述 N-terminal His6-tagged, recombinant, human ROCK-I amino acids 17-535; autoactivated by incubating with Mg/ATP and redialysed to remove excess ATP
    应用
    应用 Active, N-terminal His6-tagged, recombinant, human ROCK-I amino acids 17-535, autoactivated by incubating with Mg/ATP & redialysed to remove excess ATP. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme
    Entrez基因编号
    • NM_005406.2
    Entrez基因汇总 This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
    基因符号
    • p160-ROCK
    • ROCK1
    • P160ROCK
    • MGC131603
    • p160ROCK
    • MGC43611
    蛋白靶 ROKβ/ROCK-I
    纯化方法 Ni2+/NTA-agarose
    靶子系列 AGC
    UniProt编号
    • Q13464
    UniProt汇总 FUNCTION: SwissProt: Q13464 # Protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Necessary for apoptotic membrane blebbing. Plays a role in smooth muscle contraction. Required for centromere positioning and centromere- dependent exit from mitosis (By similarity).
    SIZE: 1354 amino acids; 158175 Da
    SUBUNIT: Binds RHOA that has been activated by GTP binding. Binds ADD1, GEM, RHOB, RHOC, myosin light chain and VIM (By similarity). Binds RHOE, PPP1R12A (MYPT1/MBS), LIMK1 and LIMK2.
    SUBCELLULAR LOCATION: Cytoplasm. Centrosome, centriole (By similarity). Golgi apparatus membrane; Peripheral membrane protein. Note=Associated with the mother centriole and an intercentriolar linker (By similarity). A small proportion is associated with Golgi membranes.
    TISSUE SPECIFICITY: Detected in blood platelets.DOMAIN:SwissProt: Q13464 The C-terminal auto-inhibitory domain interferes with kinase activity. RHOA binding leads to a conformation change and activation of the kinase. Truncated ROCK1 is constitutively activated.
    PTM: Autophosphorylated on serine and threonine residues. Phosphorylated upon DNA damage, probably by ATM or ATR. & Cleaved by caspase-3 during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.
    SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 PH domain. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain. & Contains 1 REM (Hr1) repeat.
    MISCELLANEOUS: Inhibited by Y-27632.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of Long S6 substrate peptide (Catalog #12-420)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg
    包装 Also available in 250 µg size --call for pricing and availability and reference catalog number 14-601M when ordering the 250 µg size.

    merck millipore,默克密理博,14-601,ROKβ/ROCK-I Protein, active, 10 µg

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