merck millipore,默克密理愽
  • merck millipore,默克密理博,14-598,Lambda Protein Phosphatase, GST, 250 µg

  • merck millipore,默克密理博,14-598,Lambda Protein Phosphatase, GST, 250 µg

    产品名称：Lambda Protein Phosphatase, GST, 250 µg
    产品型号：14-598
    Full-length, recombinant Lambda Protein Phosphatase (λ-PPase) with a N-terminal GST-tag. λ-PPase is a Mn2+-dependent protein phosphatase with activity towards phosphorylated serine, threonine, tyrosin More>>

    merck millipore,默克密理博,14-598,Lambda Protein Phosphatase, GST, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-598,Lambda Protein Phosphatase, GST, 250 µg

    描述
    产品目录编号 14-598
    品牌系列 Upstate
    商名
    • Upstate
    描述 Lambda Protein Phosphatase, GST, 250 µg
    概述 Full-length, recombinant Lambda Protein Phosphatase (l-PPase) with a N- terminal GST-tag, l-PPase is a Mn2+-dependent protein phosphatase with activity towards phosphorylated serine, threonine, tyrosine.

    Also included with the Lambda Protein Phosphatase, GST are a Dilution Buffer (#20-264) and a Reducing Buffer (#20-265).
    应用
    应用 Full-length, recombinant Lambda Protein Phosphatase (λ-PPase) with a N-terminal GST-tag. λ-PPase is a Mn2+-dependent protein phosphatase with activity towards phosphorylated serine, threonine, tyrosine. For use in Phosphatase Assays.
    主要应用
    • Phosphatase Assay
    应用说明 Dephosphorylation
    生物信息
    来源 expressed in E. coli.
    品种 Bacteriophage lambda
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_014634.2
    Entrez基因汇总 The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
    基因符号
    • KIAA0015
    • PPM1F
    • POPX2
    • CaMKPase
    • FEM-2
    • hFEM-2
    • Ca
    蛋白靶 Lambda Protein Phosphatase
    纯化方法 Glutathione agarose affinity chromatography
    靶子系列 Ser/Thr/Tyr/His phosphatase
    UniProt编号
    • P49593
    UniProt汇总 FUNCTION: SwissProt: P49593 # Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.
    COFACTOR: Binds 2 magnesium or manganese ions per subunit (By similarity).
    SIZE: 454 amino acids; 49831 Da
    SUBUNIT: Associates with F1Aalpha.
    SIMILARITY: SwissProt: P49593 ## Belongs to the PP2C family.
    产品使用声明
    质量保证 Used to measure the hydrolysis of p-nitrophenyl phosphate (pNPP).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg

    merck millipore,默克密理博,14-598,Lambda Protein Phosphatase, GST, 250 µg

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