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描述 产品目录编号 14-542 品牌系列 Upstate
商名 - Upstate
描述 MKK7β1 Protein, unactive, 50 µg 概述 N-terminal GST-tagged, recombinant, human MKK7β1 amino acids 2-end 应用 应用 Unactive, N-terminal GST-tagged, recombinant, human MKK7β1 amino acids 2-end, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed in E. coli 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_145185.2
Entrez基因汇总 The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. 基因符号 - Jnkk2
- MAP2K7
- MKK7
- PRKMK7
- MEK7
- MAPKK7
- JNKK2
蛋白靶 MKK7β1 纯化方法 Glutathione-agarose 靶子系列 STE UniProt编号 - O14733
UniProt汇总 FUNCTION: SwissProt: O14733 # Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.
COFACTOR: Magnesium.
SIZE: 419 amino acids; 47485 Da
SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity).
TISSUE SPECIFICITY: Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
PTM: Activated by phosphorylation on Ser/Thr.
SIMILARITY: SwissProt: O14733 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of ATF2 (amino acids 19-96) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -20°C 包装信息 数量 50 µg
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