merck millipore,默克密理愽
  • merck millipore,默克密理博,14-525M,PKC ζ Protein, active, 250 µg

  • merck millipore,默克密理博,14-525M,PKC ζ Protein, active, 250 µg

    产品名称：PKC ζ Protein, active, 250 µg
    产品型号：14-525M
    Active, N-terminal His6-tagged recombinant human PKC zeta, residues 2-end, for use in Kinase Assays.

    merck millipore,默克密理博,14-525M,PKC ζ Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-525M,PKC ζ Protein, active, 250 µg

    描述
    产品目录编号 14-525M
    品牌系列 Upstate
    商名
    • Upstate
    描述 PKC ζ Protein, active, 250 µg
    概述 N-terminal His6-tagged recombinant human PKC zeta, residues 2-end
    应用
    应用 Active, N-terminal His6-tagged recombinant human PKC zeta, residues 2-end, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002744.4
    • NM_001033581.1
    • NM_001033582.1
    Entrez基因汇总 Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
    基因符号
    • PKC2
    • PRKCZ
    • OTTHUMP00000044160
    • nPKC-zeta
    蛋白靶 PKCζ
    纯化方法 Ni2+/NTA-agarose
    靶子系列 AGC
    UniProt编号
    • Q05513
    UniProt汇总 FUNCTION: SwissProt: Q05513 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization.
    SIZE: 592 amino acids; 67660 Da
    SUBUNIT: Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B, PARD6G and SQSTM1. Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with CENTA1. Forms a ternary complex composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable). Interacts with IKBKB.
    SUBCELLULAR LOCATION: Cytoplasm. Endosome. Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes.
    TISSUE SPECIFICITY: Expressed in brain, and to a lesser extent in lung, kidney and testis.
    DOMAIN: SwissProt: Q05513 The OPR domain mediates mutually exclusive interactions with SQSTM1 and PARD6B. & The C1 domain does not bind the diacylglycerol (DAG).
    SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 OPR domain. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of PKC substrate peptide II
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-525) and in bulk (cat# 14-525-K).

    merck millipore,默克密理博,14-525M,PKC ζ Protein, active, 250 µg

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