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描述 产品目录编号 14-444M 品牌系列 Upstate
商名 - Upstate
描述 PKC θ Protein, active, 250 µg 概述 Recombinant full-length human PKC theta with a C-terminal 6His-tag
PKC Lipid activator (Catalog # 20-133) is required for use.应用 应用 Active, recombinant full-length human PKC theta with a C-terminal 6His-tag. For use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed in Sf21 cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_006257.2
Entrez基因汇总 Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. 基因符号 - nPKC-theta
- PRKCQ
- OTTHUMP00000043365
- MGC126514
- OTTHUMP00000043364
- MGC141919
- PRKCT
蛋白靶 PKCθ 纯化方法 immobilized nickel affinity chromatography 靶子系列 AGC UniProt编号 - Q04759
UniProt汇总 FUNCTION: SwissProt: Q04759 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
COFACTOR: Magnesium.
SIZE: 706 amino acids; 81865 Da
SUBUNIT: Interacts with TXNL2/PICOT.
TISSUE SPECIFICITY: Skeletal muscle, megakaryoblastic cells and platelets.
DOMAIN: SwissProt: Q04759 The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
PTM: Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation.
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of Histone H1 substrate in vitro 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70 °C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-444) and in bulk (cat# 14-444-K).
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