merck millipore,默克密理愽
  • merck millipore,默克密理博,AB3842,Anti-Cofilin Antibody

  • merck millipore,默克密理博,AB3842,Anti-Cofilin Antibody

    产品名称：Anti-Cofilin Antibody
    产品型号：AB3842
    Detect Cofilin using this Anti-Cofilin Antibody validated for use in IP & WB.

    merck millipore,默克密理博,AB3842,Anti-Cofilin Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB3842,Anti-Cofilin Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, M, MkWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB3842
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cofilin Antibody
    产品信息
    格式 Affinity Purified
    演示 Liquid in 10 mM sodium HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, with 50% glycerol.
    应用
    应用 Detect Cofilin using this Anti-Cofilin Antibody validated for use in IP & WB.
    主要应用
    • Western Blotting
    应用说明 Western blotting: 1:1,000 (for best results, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight)

    Immunoprecipitation: 1:50

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 KLH-conjugated, synthetic peptide corresponding to residues surrounding Ser3 of human cofilin.
    宿主 Rabbit
    特异性 Recognizes Cofilin, a small actin-binding protein that plays a pivotal role in cytokinesis, endocytosis, embryonic development, stress response, and tissue regeneration. This antibody may not recognize the muscle isoform cofilin 2.
    品种反应性 RatHumanMouseMonkey
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_005507.2
    Entrez基因汇总 Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. (Gillett et al., 1996 [PubMed 8800436]). Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN; MIM 609114), all of which regulate actin-filament dynamics (Bamburg et al., 1999 [PubMed 10461190]; Maciver and Hussey, 2002). The CFL2 gene encodes a skeletal muscle-specific isoform (Vartiainen et al., 2002 [PubMed 11809832]) localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins (Ono and Ono, 2002 [PubMed 11901171]).[supplied by OMIM]
    基因符号
    • p18
    • CFL1
    • CFL
    • Cofilin-1
    UniProt编号
    • Q9Y281
    • P23528
    UniProt汇总 FUNCTION: SwissProt: Q9Y281 # Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity).
    SIZE: 166 amino acids; 18737 Da
    SUBCELLULAR LOCATION: Nucleus matrix (By similarity). Cytoplasm, cytoskeleton (By similarity).
    TISSUE SPECIFICITY: Isoform CFL2b is expressed predominantly in skeletal muscle and heart, while isoform CFL2a is expressed in various tissues.
    PTM: The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
    DISEASE: SwissProt: Q9Y281 # Defects in CFL2 are the cause of nemaline myopathy type 7 (NEM7) [MIM:610687]. Nemaline myopathy (NEM) is a form of congenital myopathy characterized by abnormal thread- or rod-like structures in muscle fibers on histologic examination. The clinical phenotype is highly variable, with differing age at onset and severity.
    SIMILARITY: SwissProt: Q9Y281 ## Belongs to the actin-binding proteins ADF family. & Contains 1 ADF-H domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20ºC for 12 months, do not aliquot.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB3842,Anti-Cofilin Antibody

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下一件merck millipore产品：merck millipore,默克密理博,09-272,Anti-phospho-p38α (Thr180/Tyr182) Antibody


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