merck millipore,默克密理愽
  • merck millipore,默克密理博,04-1545,Anti-RARα Antibody, clone 9α-9A6

  • merck millipore,默克密理博,04-1545,Anti-RARα Antibody, clone 9α-9A6

    产品名称：Anti-RARα Antibody, clone 9α-9A6
    产品型号：04-1545
    Anti-RARα Antibody, clone 9α-9A6 is a Mouse Monoclonal Antibody for detection of RARα also known as Retinoic acid receptor alpha polypeptide & has been validated in WB, ICC.

    merck millipore,默克密理博,04-1545,Anti-RARα Antibody, clone 9α-9A6

  • 产品介绍
  • merck millipore,默克密理博,04-1545,Anti-RARα Antibody, clone 9α-9A6

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 04-1545
    描述 Anti-RARα Antibody, clone 9α-9A6
    Alternate Names
    • retinoic acid receptor, alpha
    • Nuclear receptor subfamily 1 group B member 1
    • Retinoic acid receptor, alpha polypeptide
    • nucleophosmin-retinoic acid receptor alpha fusion protein
    • NPM-RAR long form
    背景信息 Retinoic acid receptor alpha (RARa) is a nuclear receptor encoded by the RARA gene. This gene is sometimes referred to as NR1B1 (nuclear receptor subfamily 1, group B, member 1). RARa is a member of the steroid/thyroid superfamily of nuclear receptor proteins that regulate gene expression by binding to RNA and other elements of DNA response. As implied by its name, this protein is a receptor for retinoic acid, a metabolite of vitamin A. Retinoic acid is necessary for normal organogenesis, but can act as a teratogen when present at high levels during embryonic and fetal development. During fetal and embryonic development retinoic acid regulates transcription through the activation of nuclear receptors, specifically the Retinoic Acid Receptor (RAR). Signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), which form RXR/RAR heterodimers. There are three isoforms associated with RAR; RARα, RARβ and RARγ.
    产品信息
    格式 Ascites
    控制
    • HL60 cell lysate
    演示 Unpurified mouse monoclonal IgG1κ ascites with 0.05% sodium azide.
    应用
    应用 Anti-RARα Antibody, clone 9α-9A6 is a Mouse Monoclonal Antibody for detection of RARα also known as Retinoic acid receptor alpha polypeptide & has been validated in WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected RARα in HeLa and A431 cells.
    生物信息
    免疫原品种 Recombinant protein corresponding to human RARα.
    表位 Unknown
    克隆 clone 9α-9A6
    宿主 Mouse
    特异性 This antibody recognizes RARα.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human. Homology to mouse and rat is 91%.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000955.1
    Entrez基因汇总 Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR; see MIM 180245), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1 (MIM 600849), SMRT (NCOR2; MIM 600848), and histone deacetylase (see MIM 601241). When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases (see MIM 603053), and the basic transcription machinery. Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (MIM 102578) (Vitoux et al., 2007 [PubMed 7468032]).[supplied by OMIM].
    基因符号
    • RAR-alpha
    • NR1B1
    • RAR
    • RARA
    纯化方法 Unpurified
    UniProt编号
    • P10276
    UniProt汇总 FUNCTION: This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression.

    SIZE: 462 amino acids; 50771 Da

    SUBUNIT: Interacts with CDK7 (By similarity). Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NOCA7 in a ligand- inducible manner.

    SUBCELLULAR LOCATION: Nucleus.

    DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.

    PTM: Phosphorylated. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity (By similarity).

    DISEASE: Chromosomal aberrations involving RARA may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with ZBTB16/PLZF; translocation t(15;17)(q21;q21) with PML; translocation t(5;17)(q32;q11) with NPM.

    SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in HL60 cell lysate.

    Western Blot Analysis: 1:1,000 dilution of this antibody detected RARα on 10 µg of HL60 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-1545,Anti-RARα Antibody, clone 9α-9A6

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