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重要规格表
主要应用 Entrez基因编号 Uni Prot编号 KA NM_005321.2 P10412 描述 产品目录编号 14-155 品牌系列 Upstate
商名 - Upstate
描述 Histone H1 Protein, 20 mg Alternate Names - Linker Histone H1
背景信息 H1 and related linker histones are important both for maintenance of higher-order chromatin structure and for the regulation of gene expression. Nucleosomal stabilization is provided through the binding of histone H1 to the nucleosomal dyad and the linker DNA entering and exiting the core particle. Additional experimental evidence illustrates the influence of histone H1 on chromatin arrangement and compaction. The family of histone H1 proteins contains five somatic variants (H1.1, H1.2, H1.3, H1.4 and H1.5) which are expressed in nearly all cell types. 应用 应用 Purified bovine Histone H1 protein for use as a substrate in histone modification assays (HAT, HDAC, DNMT) and chromatin assembly studies. 主要应用 - Kinase Assay
生物信息 来源 Lysine rich fraction from calf thymus 品种 Bovine 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_005321.2
Entrez基因汇总 Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. 基因符号 - MGC116819
- HIST1H1E
- dJ221C16.5
- H1.4
- H1F4
纯化方法 Sterilized through a 0.2 micron membrane filter UniProt编号 - P10412
UniProt汇总 FUNCTION: SwissProt: P10412 # Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.
SIZE: 219 amino acids; 21865 Da
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: SwissProt: P10412 ## Belongs to the histone H1/H5 family.
MISCELLANEOUS: This variant accounts for 60% of histone H1.产品使用声明 质量保证 Routinely evaluated by Kinase assay using cdk2/cyclin A, active (14-448) to phosphorylate Histone H1. 销售限制 This product is derived from bovine source. Export of this product to certain countries may be restricted. Please contact Customer Service or your local distributor to inquire about product availability and export options. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C 包装信息 数量 20 mg
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