merck millipore,默克密理愽
  • merck millipore,默克密理博,13-118,GST-NFκB p50 subunit (δ434-969)

  • merck millipore,默克密理博,13-118,GST-NFκB p50 subunit (δ434-969)

    产品名称：GST-NFκB p50 subunit (δ434-969)
    产品型号：13-118
    N-terminal GST-tagged, recombinant human NFkB, p50 subunit (D434-969), expressed in E. coli. Purified using glutathione agarose chromatography.

    merck millipore,默克密理博,13-118,GST-NFκB p50 subunit (δ434-969)

  • 产品介绍
  • merck millipore,默克密理博,13-118,GST-NFκB p50 subunit (δ434-969)

    描述
    产品目录编号 13-118
    品牌系列 Upstate
    商名
    • Upstate
    描述 GST-NFκB p50 subunit (δ434-969)
    概述 N-terminal GST-tagged, recombinant human NFkB, p50 subunit (D434-969), expressed in E. coli. Purified using glutathione agarose chromatography. MW = 74kDa.
    产品信息
    演示 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.1mM EGTA, 0.1% βmercaptoethanol, 0.03% Brij-35, 0.2mM PMSF, 1mM benzamidine and 50% glycerol
    应用
    应用 N-terminal GST-tagged, recombinant human NFkB, p50 subunit (D434-969), expressed in E. coli. Purified using glutathione agarose chromatography.
    应用说明 DNA Binding Assay
    生物信息
    品种 Human
    Entrez基因编号
    • NM_003998.2
    Entrez基因汇总 This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.
    基因符号
    • KBF1
    • NFKB1
    • NF-kappa-B
    • DKFZp686C01211
    • MGC54151
    • NFKB-p105
    • NFKB-p50
    • EBP-1
    UniProt编号
    • P19838
    UniProt汇总 FUNCTION: SwissProt: P19838 # Appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. Plays a role in the regulation of apoptosis.
    SIZE: 968 amino acids; 105356 Da
    SUBUNIT: Active NF-kappa-B is a heterodimer of an about 50 kDa DNA-binding subunit and the weak DNA-binding subunit p65. Two heterodimers might form a labile tetramer. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL.
    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
    DOMAIN: SwissProt: P19838 The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation. & Glycine-rich region (GRR) appears to be a critical element in the generation of p50.
    PTM: While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p50 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing. & Polyubiquitination seems to allow p105 processing.
    SIMILARITY: Contains 7 ANK repeats. & Contains 1 death domain. & Contains 1 RHD (Rel-like) domain.
    产品使用声明
    质量保证 routinely evaluated in a DNA binding assay
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C
    包装信息
    数量 50 µg

    merck millipore,默克密理博,13-118,GST-NFκB p50 subunit (δ434-969)

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