merck millipore,默克密理愽
  • merck millipore,默克密理博,MABF552,Anti-CD27 Antibody (human), APC-Cy7, clone O323

  • merck millipore,默克密理博,MABF552,Anti-CD27 Antibody (human), APC-Cy7, clone O323

    产品名称：Anti-CD27 Antibody (human), APC-Cy7, clone O323
    产品型号：MABF552
    This mouse monoclonal antibody Anti-CD27 (human), APC-Cy7 & clone O323 validated for use in Flow Cytometry for the detection of CD27.

    merck millipore,默克密理博,MABF552,Anti-CD27 Antibody (human), APC-Cy7, clone O323

  • 产品介绍
  • merck millipore,默克密理博,MABF552,Anti-CD27 Antibody (human), APC-Cy7, clone O323

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMAPC-Cy7Monoclonal Antibody
    描述
    产品目录编号 MABF552
    描述 Anti-CD27 Antibody (human), APC-Cy7, clone O323
    Alternate Names
    • CD antigen CD27
    • CD27 antigen
    • CD27L receptor
    • T-cell activation antigen CD27
    • T14
    • Tumor necrosis factor receptor superfamily member 7
    背景信息 The O323 antibody reacts with human CD27 (TNFRSF7), a cell surface homodimer of 55 kDa subunits, which provides co-stimulatory signaling in support of the T cell (TCR) and B cell (BCR) receptors. By comparison with CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling appears to promote cell survival and differentiation to effector / memory stages. Also in contrast with CD28, the CD27 receptor may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells and B cells. With respect to B cells, CD27 is considered to be a phenotypic marker for memory B cells. CD27 has been included within a group of phenotypic markers for identifying human B regulatory cells (Bregs), a cell type proposed to regulate CD4+ T cell proliferation and Foxp3 / CTLA-4 expression in Treg cells.The O323 antibody may be used for analysis of CD27 expression on peripheral T cells, and is frequently used in combination with antibodies for IgD and IgM to distinguish naïve vs. memory B cell populations. For identification of Breg cells, this antibody has been used in combination with antibodies for CD25, CD27, CD1d, IL-10 and TGF-beta (Kessel et al. 2012. Autoimm. Rev. 11(9): 670-677). The antibody is also reported for cross-reactivity with Baboon, Cynomolgus and Rhesus CD27.
    产品信息
    格式 APC-Cy7
    演示 Purified Mouse Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
    应用
    应用 This mouse monoclonal antibody Anti-CD27 (human), APC-Cy7 & clone O323 validated for use in Flow Cytometry for the detection of CD27.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Immunogen information for this antibody is proprietary information.
    克隆 O323
    浓缩 5 μL (0.125 μg)/test
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    基因符号
    • TNFRSF7
    • CD27
    纯化方法 Size Exclusion Chromatography
    UniProt编号
    • P26842
    产品使用声明
    质量保证 The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

    Flow Cytometry Analysis: 0.125 μg of this antibody detected CD27 in one million human peripheral blood lymphocytes.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
    包装信息
    数量 25 tests

    merck millipore,默克密理博,MABF552,Anti-CD27 Antibody (human), APC-Cy7, clone O323

上一件merck millipore产品：merck millipore,默克密理博,AB15224,Anti-SV2A Antibody
下一件merck millipore产品：merck millipore,默克密理博,AP512F,Sheep Anti-Human IgM, (Fc), FITC conjugate Antibody


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