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merck millipore,默克密理博,126920,ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem
产品名称：ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem
产品型号：126920
The ALDH2 Agonist, Alda-1, also referenced under CAS 349438-38-6, controls the biological activity of ALDH2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
merck millipore,默克密理博,126920,ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₅H₁₁Cl₂NO₃ 349438-38-6 描述 概述 A cell-permeable benzamide compound that selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKCε activatior- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo. 产品目录编号 126920 品牌系列 Calbiochem®
同义词 N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide 参考 参考 Chen, C.H., et al. 2008. Science 321, 1493. 产品信息 CAS号 349438-38-6 声明 Patent pending. 形式 Off-white solid Hill配方 C₁₅H₁₁Cl₂NO₃ 化学配方 C₁₅H₁₁Cl₂NO₃ Molar Mass 324.2 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following, reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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