merck millipore,默克密理愽
  • merck millipore,默克密理博,124014,Akt Inhibitor VII, TAT-Akt-in - Calbiochem

  • merck millipore,默克密理博,124014,Akt Inhibitor VII, TAT-Akt-in - Calbiochem

    产品名称：Akt Inhibitor VII, TAT-Akt-in - Calbiochem
    产品型号：124014
    The Akt Inhibitor VII, TAT-Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,124014,Akt Inhibitor VII, TAT-Akt-in - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,124014,Akt Inhibitor VII, TAT-Akt-in - Calbiochem

    重要规格表

    经验配方
    C₁₅₂H₂₃₉N₅₅O₃₆
    描述
    概述 A cell-permeable and reversible version of the Akt Inhibitor VI, Akt-in (Cat. No. 124013) fused with the protein transduction domain TAT that displays antitumor properties. Inhibits the phosphorylation of Akt selectively in HEK 293 and QRsP-11 fibrosarcoma cells stimulated with PDGF (complete inhibition at ~50 µM) with minimal inhibition towards PKA, PKC, PDK1, p42/44 MAPK, or p38 MAPK. Shown to prevent the proliferation of T4 cells, and tumor growth in syngeneic C57BL/6 mice.
    产品目录编号 124014
    品牌系列 Calbiochem®
    同义词 H-YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH, TAT-TCL1₁₀₋₂₄
    参考
    参考 Hiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.
    产品信息
    具有ATP竞争性 N
    形式 White solid
    配方 Supplied as an trifluoroacetate salt.
    Hill配方 C₁₅₂H₂₃₉N₅₅O₃₆
    化学配方 C₁₅₂H₂₃₉N₅₅O₃₆
    Molar Mass 3412.9
    吸湿 Hygroscopic
    肽序列 H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
    可逆 Y
    生物信息
    主靶 Akt
    主靶IC50 50 µM against Akt
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 H₂O
    肽序列 H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,124014,Akt Inhibitor VII, TAT-Akt-in - Calbiochem

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