merck millipore,默克密理愽
  • merck millipore,默克密理博,12-243,S6 Kinase/Rsk2 Substrate Peptide 2

  • merck millipore,默克密理博,12-243,S6 Kinase/Rsk2 Substrate Peptide 2

    产品名称：S6 Kinase/Rsk2 Substrate Peptide 2
    产品型号：12-243
    S6 Kinase/Rsk2 Substrate Peptide 2 primarily used in Kinase Assays.

    merck millipore,默克密理博,12-243,S6 Kinase/Rsk2 Substrate Peptide 2

  • 产品介绍
  • merck millipore,默克密理博,12-243,S6 Kinase/Rsk2 Substrate Peptide 2

    描述
    产品目录编号 12-243
    品牌系列 Upstate
    商名
    • Upstate
    描述 S6 Kinase/Rsk2 Substrate Peptide 2
    产品信息
    演示 Lyophilized powder
    应用
    应用 S6 Kinase/Rsk2 Substrate Peptide 2 primarily used in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    Entrez基因编号
    • NM_004586.2
    Entrez基因汇总 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).
    基因符号
    • HU-3
    • RPS6KA3
    • pp90RSK2
    • S6K-alpha3
    • MAPKAPK1B
    • p90-RSK2
    • CLS
    • ISPK-1
    • ISPK1
    • RSK-2
    • MRX19
    • HU-2
    • RSK2
    • RSK
    蛋白靶 Rsk2
    靶子系列 AGC
    UniProt编号
    • P51812
    UniProt汇总 FUNCTION: SwissProt: P51812 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
    COFACTOR: Magnesium (By similarity).
    SIZE: 740 amino acids; 83736 Da
    SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
    TISSUE SPECIFICITY: Expressed in many tissues, highest levels in skeletal muscle.
    PTM: Autophosphorylated on Ser-386, as part of the activation process (By similarity). & Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369 (By similarity).
    DISEASE: SwissProt: P51812 # Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.
    SIMILARITY: SwissProt: P51812 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
    产品使用声明
    质量保证 Routinely evaluated as a substrate for p90 Rsk-2 and p70 S6 Kinase.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Lyophilized: Stable for 2 years at -20°C
    包装信息
    数量 1 mg

    merck millipore,默克密理博,12-243,S6 Kinase/Rsk2 Substrate Peptide 2

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