merck millipore,默克密理博,07-915,Anti-phospho-Syk (Tyr323) Antibody

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merck millipore,默克密理博,07-915,Anti-phospho-Syk (Tyr323) Antibody
产品名称：Anti-phospho-Syk (Tyr323) Antibody
产品型号：07-915
Anti-phospho-Syk (Tyr323) Antibody detects level of phospho-Syk (Tyr323) & has been published & validated for use in WB.

merck millipore,默克密理博,07-915,Anti-phospho-Syk (Tyr323) Antibody

产品介绍

merck millipore,默克密理博,07-915,Anti-phospho-Syk (Tyr323) Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-915
品牌系列	Upstate
商名	Upstate
描述	Anti-phospho-Syk (Tyr323) Antibody
Alternate Names	spleen tyrosine kinase

产品信息
格式	Affinity Purified
演示	100 µL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.

应用
应用	Anti-phospho-Syk (Tyr323) Antibody detects level of phospho-Syk (Tyr323) & has been published & validated for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	Peptide corresponding to amino acid region encompassing the human and mouse phospho-Syk Tyr323 of human and Tyr 317 of mouse.
宿主	Rabbit
特异性	Recognizes phospho-Syk (Tyr323)
同种型	IgG
品种反应性	Human
Species Reactivity Note	Predicted to cross-react with Mouse based on sequence homology.
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_003177.3
基因符号	SYK
修改	Phosphorylation
纯化方法	Immunoaffinity purified
UniProt编号	P43405
UniProt汇总	FUNCTION: SwissProt: P43405 # Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion (By similarity). SIZE: 635 amino acids; 72066 Da SUBUNIT: Interacts with CBL and SLA when it is phosphorylated. The interaction with SLA may link it to CBL, leading to its destruction. Interacts with phosphorylated NFAM1 (By similarity). Interacts with Epstein-Barr virus LMP2A. Interacts through its SH2 domains with the phosphorylated ITAM domain of CD79A which stimulates SYK autophosphorylation and activation. PTM: Autophosphorylated. & Phosphorylation on Tyr-323 creates a binding site for c-Cbl, an adapter protein that serves as a negative regulator of BCR- stimulated calcium ion signaling (By similarity). & Phosphorylation on Tyr-348 and Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3- kinase-independent pathway (By similarity). & Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation (By similarity). SIMILARITY: SwissProt: P43405 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. & Contains 1 protein kinase domain. & Contains 2 SH2 domains.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 2 years at -20°C from date of shipment.
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.