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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB M Culture Supernatant Monoclonal Antibody 描述 产品目录编号 05-430 品牌系列 Upstate
商名 - Upstate
描述 Anti-INK4b (p15) Antibody 产品信息 格式 Culture Supernatant 演示 culture supernatant with 0.05% sodium azide 应用 应用 Detect INK4b (p15) with Anti-INK4b (p15) Antibody (Mouse Monoclonal Antibody), that has been shown to work in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Full length fusion protein correspond-ing to human p15 sequence 宿主 Mouse 特异性 p15 同种型 IgG1 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004936
Entrez基因汇总 This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. 基因符号 - p15_INK4B
- CDKN2B
- TP15
- p15INK4b
- p14-INK4b
- MTS2
- p15-INK4b
- p14_INK4B
- p15INK4B
- INK4B
- P15
- CDK4I
UniProt编号 - P42772
UniProt汇总 FUNCTION: SwissProt: P42772 # Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
SIZE: 138 amino acids; 14722 Da
SUBUNIT: Heterodimer of CDKN2B with CDK4 or CDK6.
DISEASE:SwissProt: P42772 # Defects in CDKN2B are involved in tumor formation.
SIMILARITY: SwissProt: P42772 ## Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. & Contains 4 ANK repeats.产品使用声明 质量保证 Routinely evaluated by immunoblot on RIPA lysates from HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 400 µL
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