merck millipore,默克密理愽
  • merck millipore,默克密理博,205536,Cadein1 - Calbiochem

  • merck millipore,默克密理博,205536,Cadein1 - Calbiochem

    产品名称：Cadein1 - Calbiochem
    产品型号：205536
    A cell-permeable isoquinolinium compound that preferentially induces apoptotic cell death in p53-deficient cancer cells with functional MMR (DNA mismatch repair) system.

    merck millipore,默克密理博,205536,Cadein1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,205536,Cadein1 - Calbiochem

    重要规格表

    经验配方
    C₃₃H₄₈F₂INO₂
    描述
    概述 A cell-permeable isoquinolinium compound that preferentially induces apoptotic cell death in p53-deficient cancer cells with functional MMR (DNA mismatch repair) system, including HCT116-Ch3/E6, HeLa, HT29, and SW620 (viability <19 %; 4-6 µM Cadein1 for 24 h), while exhibiting much reduced potency in MMR-/p53+ (RKO and HCT116), MMR-/p53- (DLD-1 and HCT116-E6), and MMR+/p53+ (HCT116-Ch3 and HEK293) cancer cultures (viability = 40 to 92%; 4 µM Cadein1 for 24 h).
    产品目录编号 205536
    品牌系列 Calbiochem®
    同义词 1-Pentadecyl-6,7-dimethoxy-2-(2,6-difluorobenzyl)-3,4-dihydroisoquinolium chloride, Cancer-selective death inducer 1
    参考
    参考 Jang, E.R., et al. 2010. J. Biol. Chem. 285, 2986.
    产品信息
    形式 Yellow powder
    Hill配方 C₃₃H₄₈F₂INO₂
    化学配方 C₃₃H₄₈F₂INO₂
    Molar Mass 655.7
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,205536,Cadein1 - Calbiochem

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