merck millipore,默克密理愽
  • merck millipore,默克密理博,662009,InSolution™ U0126 - CAS 109511-58-2 - Calbiochem

  • merck millipore,默克密理博,662009,InSolution™ U0126 - CAS 109511-58-2 - Calbiochem

    产品名称：InSolution™ U0126 - CAS 109511-58-2 - Calbiochem
    产品型号：662009
    A potent and specific inhibitor of MEK1 and MEK2 .

    merck millipore,默克密理博,662009,InSolution™ U0126 - CAS 109511-58-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,662009,InSolution™ U0126 - CAS 109511-58-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₆N₆S₂•½C₂H₅OH109511-58-2
    描述
    概述 A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z), E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.
    产品目录编号 662009
    品牌系列 Calbiochem®
    参考
    参考 Duncia, J.V., et al. 1998. Bioorg. Med. Chem. Lett. 8, 2839.
    产品信息
    CAS号 109511-58-2
    形式 Liquid
    配方 A 100 mM (5 mg/124 µl) solution of U0126 (Cat. No. 662005) in DMSO.
    Hill配方 C₁₈H₁₆N₆S₂•½C₂H₅OH
    化学配方 C₁₈H₁₆N₆S₂•½C₂H₅OH
    Molar Mass 403.5
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    安全信息
    R相 R: 36/38

    Irritating to eyes and skin.
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Irritant
    储存 ≤ -70°C
    避光 Protect from light
    吸湿 Hygroscopic
    避免冻结 / 解冻 Avoid freeze/thaw
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot into precooled vials, freeze immediately at (-70°C).
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,662009,InSolution™ U0126 - CAS 109511-58-2 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,CBL714,Anti-CD126 Antibody, clone B-R6
下一件merck millipore产品：merck millipore,默克密理博,487950,NOC-5 - CAS 146724-82-5 - Calbiochem


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