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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, ELISA, FC M Purified Monoclonal Antibody 描述 产品目录编号 CBL714 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD126 Antibody, clone B-R6 Alternate Names - IL-6 Receptor, alpha Chain
- IL-6 Receptor
产品信息 格式 Purified 演示 The monoclonal was purified by ion exchange chromatography and is presented as a liquid in phosphate buffered saline, pH 7.4, containing 0.09% sodium azide. 应用 应用 This Anti-CD126 Antibody, clone B-R6 is validated for use in ELISA, FC, IP, IH for the detection of CD126. 主要应用 - Immunohistochemistry
- ELISA
- Flow Cytometry
应用说明 Flow cytometry: 1:50. Use 10 μL of this dilution to label 10e6 cells in 100 μL.
Immunohistochemistry on frozen sections.
Immunoprecipitation.
ELISA
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 CHO cells transfected with a cDNA of the human IL-6 receptor. 克隆 B-R6 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes both the soluble and membrane bound human IL-6 receptor. The antibody will inhibit IL-6 mediated proliferation of XG-1 cells and partially blocks the binding of IL-6 to its receptor. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_181359.1
- NM_000565.2
Entrez基因汇总 Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. 基因符号 - IL-6R-1
- IL6R
- MGC104991
- IL-6R-alpha
- IL6RA
- CD126
- gp80
UniProt编号 - P08887
UniProt汇总 FUNCTION: SwissProt: P08887 # Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
SIZE: 468 amino acids; 51548 Da
SUBUNIT: Hexamer of two molecules each of IL6, IL6R and IL6ST.
SUBCELLULAR LOCATION: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
DOMAIN: SwissProt: P08887 The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain. & The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding.
PTM: A short soluble form may also be released from the membrane by proteolysis.
SIMILARITY: Belongs to the type I cytokine receptor family. Type 3 subfamily. & Contains 1 fibronectin type-III domain. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2°-8°C for up to 12 months from date of receipt in undiluted aliquots. 包装信息 数量 100 µg
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