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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1825 描述 Anti-FRS3/FRS2β Antibody Alternate Names - suc1-associated neurotrophic factor target 2 (FGFR<br />signalling adaptor)
- FGFR substrate 3
- FGFR-signaling adaptor SNT2
- Suc1-associated neurotrophic factor target 2
- fibroblast growth factor receptor substrate 3
背景信息 Fibroblast growth factor receptor substrate 3 (FRS3) is an adapter protein that is tyrosine phosphorylated and recruited to FGFR upon FGF stimulation. FRS3 is also designated as FRS2 and SNT2 (Suc1 associated neurotrophic factor target protein). 产品信息 格式 Affinity Purified 控制 - Mouse brain tissue lysate
演示 Purified rabbit serum in PBS containing 0.05% sodium azide. 应用 应用 Anti-FRS3/FRS2β Antibody detects level of FRS3/FRS2β & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to amino acids 361-375 of FRS3/ FRS2β. 表位 PTB 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes FRS3/ FRS2β. 品种反应性 RatHumanMouse Species Reactivity Note Proven to react with human, mouse, and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_659188
基因符号 - SNT2
- FRS2-beta
- FRS2B
- FRS2beta
- MGC17167
- OTTHUMP00000016383
- OTTHUMP00000039786
- SNT-2
纯化方法 Affinity Purfied UniProt编号 - O43559
UniProt汇总 FUNCTION: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
SUBUNIT STRUCTURE: Binds NTRK1 By similarity. Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2.
SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
PTM: Phosphorylated on tyrosine residues upon stimulation by BFGF or NGFB.
SEQUENCE SIMILARITIES: Contains 1 IRS-type PTB domain.
产品使用声明 质量保证 Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: A 1:2,000 dilution of this antibody detected FRS3/ FRS2β in mouse brain tissue lysate.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C for 1 year from date of receipt. 包装信息 数量 100 µg
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