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  • merck millipore,默克密理博,ABE1294,Anti-Early B-cell factor (EBF1) Antibody

  • merck millipore,默克密理博,ABE1294,Anti-Early B-cell factor (EBF1) Antibody

    产品名称：Anti-Early B-cell factor (EBF1) Antibody
    产品型号：ABE1294
    This Anti-Early B-cell factor (EBF1) Antibody is validated for use in western blotting & ChIP for the detection of Early B-cell factor (EBF1).

    merck millipore,默克密理博,ABE1294,Anti-Early B-cell factor (EBF1) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE1294,Anti-Early B-cell factor (EBF1) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MChIP, WBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE1294
    描述 Anti-Early B-cell factor (EBF1) Antibody
    Alternate Names
    • EBF1
    • Transcription factor COE1
    • O/E-1
    • OE-1
    • Early B-cell factor
    背景信息 The family of Early B-cell Factor (EBF) or Collier/Olf-1/EBF (COE) proteins, EBF1, EBF2, and EBF3, are ubiquitous zinc-binding transcription factors found in many species, including human, Drosophila melanogaster, and Caenorhabditis elegans. EBF1 is abundantly expressed in early B-cells, lymph node, spleen, and adipose tissue. Low levels of EBF1 have also been detected in the brain, heart, skeletal muscle, and kidney. EBF proteins are capable of forming homo- and heterodimers that bind to DNA at specific sites. EBF1, the prototypical member of this family, may employ epigenetic mechanisms, such as DNA methylation and chromatin remodeling, to regulate genes involved in B-cell development such as Pax5. The second member of this family EBF2 is involved in bone development, adipogenesis, and CNS development, processes which may also hinge on EBF1. EBF3 has been characterized as a tumor suppressor protein, due to its role in regulating multiple genes such as those for cyclins and CDKs which control cell growth, differentiation, and apoptosis. However, emerging evidence indicates that all EBF proteins may play a role in the development of various cancers.
    产品信息
    格式 Purified
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Early B-cell factor (EBF1) Antibody is validated for use in western blotting & ChIP for the detection of Early B-cell factor (EBF1).
    主要应用
    • Chromatin Immunoprecipitation (ChIP)
    • Western Blotting
    应用说明 Chromatin Immunoprecipitation Analysis: A representative lot from an independent laboratory detected Early B-cell factor (EBF1) in mouse primary pro-B cells (Trieber, T., et al. (2010). Immunity. 32(5):714-725.).
    生物信息
    免疫原品种 Linear peptide corresponding to human Early B-cell factor (EBF1).
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 Mouse
    Species Reactivity Note Mouse. Predicted to react with Human based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_076870
    基因符号
    • EBF
    • COE1
    纯化方法 Protein G purified
    UniProt编号
    • Q9UH73
    产品使用声明
    质量保证 Evaluated by Western Blotting in 38B9 cell lysate.

    Western Blotting Analysis: 1 µg/mL of this antiboyd detected Early B-cell factor (EBF1) in 10 µg of 38B9 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABE1294,Anti-Early B-cell factor (EBF1) Antibody

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