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merck millipore,默克密理博,07-718,Anti-Histone H2A.Z Antibody
产品名称：Anti-Histone H2A.Z Antibody
产品型号：07-718
Anti-Histone H2A.Z Antibody is a Rabbit Polyclonal Antibody for detection of Histone H2A.Z also known as H2AZ histone & has been validated in WB.
merck millipore,默克密理博,07-718,Anti-Histone H2A.Z Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Yeast WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-718 商名 - Upstate
描述 Anti-Histone H2A.Z Antibody Alternate Names - Htz1
- H2AZ, HTA3, H2AZ
背景信息 H2A.Z, also known as H2AFZ, is a variant of histone H2A variant that is highly conserved from yeast to humans. Like other histone variants, H2A.Z is encoded by a unique gene, resulting in a slightly divergent type of H2A with specialized functions. H2A.Z is involved in chromatin compaction by stabilizing the histone octamer within the nucleosome. It promotes gene expression through the creation of an open domain of chromatin that is more easily transcribed. H2A.Z is nonrandomly distributed throughout the genome, targeted primarily to pericentric heterochromatin, but excluded from the inactive X chromosome and the nucleolus. H2A.Z is associated with both euchromatin and facultative heterochromatin. DNA methylation can influence chromatin structure and effect gene silencing by excluding H2A.Z, and likewise, H2A.Z protects genes from DNA methylation. Thus, H2A.Z plays a role in regulating heterochromatin silencing and is involved in transcriptional control. 产品信息 格式 Affinity Purified 控制 - Yeast whole cell extract
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Histone H2A.Z Antibody is a Rabbit Polyclonal Antibody for detection of Histone H2A.Z also known as H2AZ histone & has been validated in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of yeast Histone H2A.Z. 表位 C-terminus. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the C-terminus of Histone H2A.Z. 品种反应性 Yeast Species Reactivity Note Demonstrated to react with Yeast. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_014631.1
基因符号 - O2345
- HTZ1
- H2AZ
- HTA3
- OL012C
纯化方法 Affinity purified UniProt编号 - Q12692
UniProt汇总 FUNCTION: Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.
SUBUNIT STRUCTURE: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms an heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Interacts also with RBP1/DNA-directed RNA polymerase II largest subunit. Interacts with NAP1.
SUBCELLULAR LOCATION: Nucleus. Chromosome.产品使用声明 质量保证 Evaluated by Western Blot in yeast whole cell extract.
Western Blot Analysis: 0.05 µg/mL of this antibody detected Histone H2A.Z in 6 µL of yeast whole cell extract.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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