merck millipore,默克密理博,ABD135,Anti-NANOS3 Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABD135
描述	Anti-NANOS3 Antibody
Alternate Names	NOS3 Nanos homolog 3 NOS-3
背景信息	Nanos homolog 3 (Nanos3), also known as NOS-3 or NOS3, belongs to the Nanos family. Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. Nanos3 has been shown to play an important role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Nanos3 has also been shown to be essential in the early stage embryo protecting the migrating primordial germ cells (PGCs) from apoptosis. Additionally, it is implied to maintain the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways and to affect cell proliferation by repressing translation of specific mRNAs. Nanos3 is expressed primarily in ovary, testis and brain. In the ovaries, Nanos3 is expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, Nonos3 is expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids.

产品信息
格式	Affinity Purified
控制	Human brain tissue lysate
演示	Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

应用
应用	Detect Nanos homolog 3 using this rabbit polyclonal antibody, Anti-NANOS3 Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.
主要应用	Western Blotting
应用说明	Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected NANOS3 in human brain tissue. Immunofluorescence Analysis: 20 μg/mL from a representative lot detected NANOS3 in human brain cells.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to the C-terminus of human NANOS3.
表位	C-terminus
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	This antibody recognizes the C-terminus of NANOS3.
品种反应性	Human
抗体类型	Polyclonal Antibody
基因符号	Nanos3 NANOS3
纯化方法	Antigen Affinity purified
UniProt编号	P60323

产品使用声明
质量保证	Evaluated by Western Blotting in human brain tissue lysate. Western Blotting Analysis: 2 µg/mL of this antibody detected NANOS3 in 15 µg of human brain tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,ABD135,Anti-NANOS3 Antibody

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