merck millipore,默克密理博,07-706,Anti-WDR5 Antibody

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merck millipore,默克密理博,07-706,Anti-WDR5 Antibody
产品名称：Anti-WDR5 Antibody
产品型号：07-706
Detect WDR5 using this Anti-WDR5 Antibody validated for use in WB.

merck millipore,默克密理博,07-706,Anti-WDR5 Antibody

产品介绍

merck millipore,默克密理博,07-706,Anti-WDR5 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-706
品牌系列	Upstate
商名	Upstate
描述	Anti-WDR5 Antibody
Alternate Names	WD-repeat protein 5 WD repeat-containing protein 5 SWD3 Set1c WD40 repeat protein homolog Cilia and flagella associated protein 89 BMP2-induced 3-kb gene protein BIG3
背景信息	WD repeat-containing protein 5 (also known as BMP2-induced 3-kb gene protein, WD repeat-containing protein 5, WD-repeat protein 5, Set1c WD40 repeat protein homolog, cilia and flagella associated protein 89) is a nuclear protein encoded by the WDR5 (also known as BIG3, CFAP89, SWD3) gene in human. This protein contains 7 WD (Trp-Asp) repeats and belongs to the WD repeat protein family whose members are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WD repeat-containing protein 5 is a component of several complexes that regulate histone methylation and acetylation levels, including ATAC (ADA2A-containing complex) complex, SET1 complex, MLL1/MLL, MLL2/3 (also named ASCOM complex), MLL4/WBP7, and NSL (non-specific lethal) complex.

产品信息
格式	Affinity Purified
演示	Purified rabbit polyclonal IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide with 30% glycerol.

应用
应用	Detect WDR5 using this Anti-WDR5 Antibody validated for use in WB.
主要应用	Western Blotting
应用说明	Western Blot: 0.05-0.25 μg/mL using HeLa nuclear extracts.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to the N-terminus of human WDR5.
表位	Near N-terminus
浓缩	Please refer to lot specific datasheet.
宿主	Rabbit
特异性	Recognizes WDR5, MW 36 kDa. A related protein band of 43 kDa that was blocked by the immunizing peptide was also detected. Identification of WDR5 protein at 36 kDa was confirmed with siRNA knockdown by an independent laboratory.
同种型	IgG
品种反应性	Human
Species Reactivity Note	Evaluated by Western Blotting in HeLa nuclear extract. Western Blotting Analysis: A 1:4,000 dilution of this antibody detected WDR5 in 10 µg of HeLa nuclear extract.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_060058
Entrez基因汇总	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
基因符号	WDR5 BIG-3 BIG3 CFAP89 SWD3
纯化方法	Affinity purified
UniProt编号	P61964

产品使用声明
质量保证	Evaluated by Western Blotting in HeLa nuclear extract. Western Blotting Analysis: A 1:4,000 dilution of this antibody detected WDR5 in 10 µg of HeLa nuclear extract.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.