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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-674 品牌系列 Upstate
商名 - Upstate
描述 Anti-Na+K+ ATPase α-2 Antibody 产品信息 格式 Serum 应用 应用 Anti-Na+K+ ATPase α-2 Antibody is an antibody against Na+K+ ATPase α-2 for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide (CKAGQENISVSKRDT) corresponding to amino acids 432-445 of human Na+K+ ATPase α-2, with an N-terminal cysteine added for conjugation purposes. 宿主 Rabbit 特异性 Na+/K+ ATPase α-2 同种型 IgG 品种反应性 Rat Species Reactivity Note Predicted to crossreact with human, mouse, dog and monkey based on sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000702.2
Entrez基因汇总 The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. 基因符号 - +K
- ATP1A2
- FHM2
- MGC59864
- KIAA0778
- MHP2
- Na
纯化方法 Antiserum UniProt编号 - P50993
UniProt汇总 FUNCTION: SwissProt: P50993 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
SIZE: 1020 amino acids; 112265 Da
SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
DISEASE: SwissProt: P50993 # Defects in ATP1A2 are the cause of familial hemiplegic migraine 2 (FHM2) [MIM:602481]. Familial hemiplegic migraine is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis. & Defects in ATP1A2 are a cause of alternating hemiplegia of childhood (AHC) [MIM:104290]. AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age.
SIMILARITY: SwissProt: P50993 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.产品使用声明 质量保证 Routinely evaluated by immunoblot with rat brain microsomal preparation (catalog# 12-144) 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 2 years at -20°C from date of shipment 包装信息 数量 200 µL
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