merck millipore,默克密理愽
  • merck millipore,默克密理博,07-303,Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody

  • merck millipore,默克密理博,07-303,Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody

    产品名称：Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody
    产品型号：07-303
    Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody is an antibody against phospho-Acetyl CoA Carboxylase (Ser79) for use in WB.

    merck millipore,默克密理博,07-303,Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-303,Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    B, H, M, R, Ca, ChWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-303
    Replaces 04-1009
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody
    Alternate Names
    • acetyl-Coenzyme A carboxylase alpha
    • acetyl-CoA carboxylase 1
    • acetyl-CoA carboxylase-alpha
    背景信息 Acetyl CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is a multi-subunit enzyme in most prokaryotes, whereas it is a large, multi-domain enzyme in most eukaryotes. The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification. Human genome contains the genes for two different ACCs - ACACA and ACACB. The activity of the enzyme is controlled by the reversible phosphorylation. The activities of the enzyme is inhibited if phosphorylated; the phosphorylation takes place when the hormones, glucagon or epinephrine bind to the receptors or the energy status of the cell is low, leading to the activation of the AMP-activated protein kinase. The presence of fatty acid inhibits the activities of the enzyme. When insulin binds to its receptors of the cell, it activates a phosphatase to dephosphorylate the enzyme; the activities of the acetyl CoA carboxylase is thus enhanced. Acetyl CoA carboxylase has recently become a target in the design of new anti-obesity and antibiotic drugs.
    产品信息
    格式 Purified
    演示 Protein A purified in buffer containing in 0.1M Tris-Glycine (pH7.4), 150 mM NaCl, with 0.05% NaN3.
    应用
    应用 Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody is an antibody against phospho-Acetyl CoA Carboxylase (Ser79) for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH conjugated synthetic peptide (C-HM RSSM[pS]GLHLVK) corresponding to amino acid 73-85 of rat Acetyl CoA Carboxylase.
    表位 N-terminal
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Acetyl CoA Carboxylase phosphorylated at Serine 79, MW 257 kDa.
    品种反应性 BovineHumanMouseRatCanineChicken
    Species Reactivity Note Human. Expected to react with Cow, Dog, Chicken, Rat and Mouse based on immunogen sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_942131
    Entrez基因汇总 Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
    基因符号
    • ACAC
    • ACACA
    • ACC-alpha
    • ACCA
    • ACC
    • ACC1
    修改
    • Phosphorylation
    纯化方法 Protein A chromatography
    UniProt编号
    • Q13085
    UniProt汇总 FUNCTION: SwissProt: Q13085 # Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
    COFACTOR: Biotin. & Binds 2 manganese ions per subunit.
    SIZE: 2346 amino acids; 265554 Da
    SUBUNIT: Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis.
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.
    PTM: Phosphorylation on Ser-1263 is required for interaction with BRCA1.
    SIMILARITY: SwissProt: Q13085 ## Contains 1 ATP-grasp domain. & Contains 1 biotin carboxylation domain. & Contains 1 biotinyl-binding domain. & Contains 1 carboxyltransferase domain.
    产品使用声明
    质量保证 Evaluated by Western Blot on Lambda phosphatase-treated and untreated A375 cell lysate.

    Western Blot Analysis: 1:500 dilution of this antibody detected endogenous phospho-Acetyl CoA Carboxylase (Ser79) in lysate from Lambda phosphatase-treated and untreated A375 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,07-303,Anti-phospho-Acetyl CoA Carboxylase (Ser79) Antibody

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