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品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-625 品牌系列 Upstate
商名 - Upstate
描述 Anti-ATRIP Antibody 概述 Antibody recognizing ATR-Interacting Protein 产品信息 格式 Purified 演示 70% storage buffer (0.05M Tris-glycine, 0.025M sodium phosphate, pH 7.4, 0.15M NaCl, 0.035% sodium azide) and 30% glycerol 应用 应用 Detect ATRIP with Anti-ATRIP Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 GST fusion protein corresponding to residues 1-181 of human ATR interacting protein (ATRIP) 宿主 Rabbit 特异性 ATRIP 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - AF451323
Entrez基因汇总 The product of this gene is an essential component of the DNA damage checkpoint, and binds to single-stranded DNA coated with replication protein A that accumulates at sites of DNA damage. The encoded protein interacts with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase, resulting in accumulation of the kinase at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. 基因符号 - MGC26740
- ATRIP
- MGC20625
- DKFZp762J2115
- FLJ12343
- AGS1
- MGC21482
纯化方法 Protein G purfied UniProt编号 - Q8WXE1
UniProt汇总 FUNCTION: SwissProt: Q8WXE1 # Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
SIZE: 791 amino acids; 85838 Da
SUBUNIT: Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA.
SUBCELLULAR LOCATION: Nucleus. Note=Redistributes to discrete nuclear foci upon DNA damage.
TISSUE SPECIFICITY: Ubiquitous.
DOMAIN:SwissProt: Q8WXE1 The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.
PTM: Phosphorylated by ATR.
SIMILARITY: Belongs to the ATRIP family.产品使用声明 质量保证 Routinely evaluated by immunoblot on modified RIPA lysates from HEK293, HeLa and U20S cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µL
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