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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-239 品牌系列 Upstate
商名 - Upstate
描述 Anti-mGluR7 Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect mGluR7 using this Anti-mGluR7 Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide (C-NSPAAKKKYVSYNN) corresponding to amino acids 899-912 of human mGluR7 宿主 Rabbit 特异性 mGluR7 同种型 IgG 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000831
Entrez基因汇总 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined. 基因符号 - FLJ40498
- GRM7
- GLUR7
- mGlu7
- mGluR7
- MGLUR7
- GPRC1G
纯化方法 Protein A chromatography UniProt编号 - Q14831
UniProt汇总 FUNCTION: SwissProt: Q14831 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
SIZE: 915 amino acids; 102251 Da
SUBUNIT: Interacts with PRKCABP (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.
SIMILARITY: SwissProt: Q14831 ## Belongs to the G-protein coupled receptor 3 family.产品使用声明 质量保证 routinely evaluated by immunoblot on rat brain microsomal preparation 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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