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经验配方 C₁₁H₉N₅O 描述 概述 A cell-permeable, ATP-binding site-targeting azaindolopyrimidine compound that inhibits against Cdk2/A, Cdk9/T, DYRK1A, Cdk5/p25, CK1δ/ε, Cdk1/B, and GSK-3α/β kinase activity (IC50 = 18, 18, 35, 50, 50, 57, and 500 nM, respectively). Shown to induce DEVDase activity in SH-SY5Y neuroblastoma cultures (by 5.46-fold in 24 h at 1 µM) and exhibit antiproliferative activity toward SH-SY5Y, multiple myeloma KMS-11, human embryonic kidney HEK293, colorectal adenocarcinoma LS 174T, and glioma GBM cells in vitro (IC50 = 0.41, 0.6, 0.96, 1.06, and 1.21 µM, respectively). 产品目录编号 445820 品牌系列 Calbiochem®
同义词 3-((2-Amino)pyrimidin-4-yl)-4-hydroxy-1H-pyrrolo[2,3-b]pyridine 参考 参考 Echalier, A., et al. 2008. J. Med. Chem. 51, 737.
Bettayeb, K., et al. 2007. Cancer Res. 67, 8325.产品信息 形式 Yellow solid Hill配方 C₁₁H₉N₅O 化学配方 C₁₁H₉N₅O Molar Mass 227.2 结构配方图像 生物信息 纯度 ≥93% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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