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  • merck millipore,默克密理博,07-2123,Anti-Ras-related protein Ral-A Antibody

  • merck millipore,默克密理博,07-2123,Anti-Ras-related protein Ral-A Antibody

    产品名称：Anti-Ras-related protein Ral-A Antibody
    产品型号：07-2123
    Anti-Ras-related protein Ral-A Antibody is a highly specific rabbit polyclonal antibody, that targets Ral & has been tested in western blotting & ICC.

    merck millipore,默克密理博,07-2123,Anti-Ras-related protein Ral-A Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-2123,Anti-Ras-related protein Ral-A Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-2123
    描述 Anti-Ras-related protein Ral-A Antibody
    Alternate Names
    • v-ral simian leukemia viral oncogene homolog A (ras related)
    • RAS-like protein A
    • Ras family small GTP binding protein RALA
    • Ras-related protein Ral-A
    • ras related v-ral simian leukemia viral oncogene homolog A
    背景信息 RalA and RalB are Ras-family small monomeric GTPases that can be activated through a Ras-dependent mechanism. The two are highly homologous (89%). Ral proteins are proximal effectors of oncogenic Ras and their activity is needed to support tumorigenesis in certain cancers. Mutants of Ras that are defective in activating all known Ras effectors except Ral GEF are still able to induce invasive phenotypes in transfected cells, suggesting a role for Ral in these processes. RalA is required for anchorage-independent proliferation and tumorigeneisis by driving exocyst assembly and polarized exocytosis in epithelial cells.
    产品信息
    格式 Affinity Purified
    控制
    • HeLa cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Anti-Ras-related protein Ral-A Antibody is a highly specific rabbit polyclonal antibody, that targets Ral & has been tested in western blotting & ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected Ras-related protein Ral-A in A431 cells.
    生物信息
    免疫原品种 Linear peptide corresponding to human Ras-related protein Ral-A.
    表位 Unknown
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes Ras-related protein Ral-A.
    同种型 IgG
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human, mouse, and rat.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_005393
    Entrez基因汇总 The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq].
    基因符号
    • RALA
    • RAL
    纯化方法 Affinity Purfied
    UniProt编号
    • P11233
    UniProt汇总 SUBUNIT STRUCTURE; Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1.

    SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

    SEQUENCE SIMILARITIES: Belongs to the small GTPase superfamily. Ras family.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 0.25 µg/mL of this antibody detected Ras-related protein Ral-A on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-2123,Anti-Ras-related protein Ral-A Antibody

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