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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-207 Replaces AB9572 品牌系列 Upstate
商名 - Upstate
描述 Anti-Numb (pan-isoform) Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 This Anti-Numb (pan-isoform) Antibody is validated for use in WB for the detection of Numb (pan-isoform). 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide corresponding the C-terminus common to all four isoforms of mouse Numb (C-TNPFSSDLQKTFEIEL) containing an N-terminal cysteine 宿主 Rabbit 特异性 Recognizes all 4 Numb isoforms 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_010949
Entrez基因汇总 The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. 基因符号 - h-Numb
- NUMB
- S171
纯化方法 Protein A purfied UniProt编号 - P49757
UniProt汇总 FUNCTION: SwissProt: P49757 # Implicated in the control of cell fate decisions during development.
SIZE: 651 amino acids; 70804 Da
SUBUNIT: Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
PTM: Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
SIMILARITY: SwissProt: P49757 ## Contains 1 PID domain.产品使用声明 质量保证 routinely evaluated by immunoblot on modified RIPA lysates from A431 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 200 µg
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