merck millipore,默克密理愽
  • merck millipore,默克密理博,05-718,Anti-PML Antibody, clone 36.1-104

  • merck millipore,默克密理博,05-718,Anti-PML Antibody, clone 36.1-104

    产品名称：Anti-PML Antibody, clone 36.1-104
    产品型号：05-718
    Detect PML also known as Promyelocytic Leukemia Protein with Anti-PML Antibody, clone 36.1-104 (Mouse Monoclonal Antibody), that has been demonstrated to work in ICC & WB.

    merck millipore,默克密理博,05-718,Anti-PML Antibody, clone 36.1-104

  • 产品介绍
  • merck millipore,默克密理博,05-718,Anti-PML Antibody, clone 36.1-104

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MWB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-718
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-PML Antibody, clone 36.1-104
    背景信息 Promyeloctic Leukemia Gene product (PML) is a nuclear protein with growth-suppressive properties originally identified in the context of the PML-retinoic receptor alpha (RAR alpha) fusion protein of acute promyelocytic leukemia. PML localizes within distinct nuclear structures, called nuclear bodies, which are disrupted by the expression of PML-RAR alpha.
    产品信息
    格式 Purified
    控制
    • MEF1 cell lysate
    演示 Protein G Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide as a preservative.
    应用
    应用 Detect PML also known as Promyelocytic Leukemia Protein with Anti-PML Antibody, clone 36.1-104 (Mouse Monoclonal Antibody), that has been demonstrated to work in ICC & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    生物信息
    免疫原品种 6His fusion protein corresponding to mouse PML (promyelocytic leukemia protein)
    克隆 36.1-104
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes PML.
    同种型 IgG
    品种反应性 Mouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_033238
    Entrez基因汇总 The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
    基因符号
    • MYL
    • PML
    • PP8675
    • RNF71
    • TRIM19
    纯化方法 Protein G purfied
    UniProt编号
    • P29590
    UniProt汇总 FUNCTION: SwissProt: P29590 # Probable transcription factor. May play an important role in recruitment of ELF4 into PML nuclear bodies.
    SIZE: 882 amino acids; 97517 Da
    SUBUNIT: Interacts with SIRT1, TOPBP1, TRIM27 and TRIM69. Interacts with the C-terminus of ELF4. Interacts with Lassa virus Z protein and rabies virus phosphoprotein (By similarity).
    SUBCELLULAR LOCATION: Nucleus. Note=Localized to PML nuclear bodies.
    PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
    DISEASE: SwissProt: P29590 # A chromosomal aberration involving PML may be a cause of acute promyelocytic leukemia (APL). Translocation t(15;17)(q21;q21) with RARA. The PML breakpoints (type A and type B) lie on either side of an alternatively spliced exon.
    SIMILARITY: SwissProt: P29590 ## Contains 2 B box-type zinc fingers. & Contains 1 RING-type zinc finger.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from mouse embryo fibroblast (MEF1) cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-718,Anti-PML Antibody, clone 36.1-104

上一件merck millipore产品：merck millipore,默克密理博,AB5210-50UL,Anti-Sodium Channel Antibody, Voltage Gated, Pan (SP19 Segment)
下一件merck millipore产品：merck millipore,默克密理博,05-1947,Anti-USP7 Antibody, clone 7G9


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