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merck millipore,默克密理博,07-1813,Anti-Septin-2 Antibody
产品名称：Anti-Septin-2 Antibody
产品型号：07-1813
Use Anti-Septin-2 Antibody (Rabbit Polyclonal Antibody) validated in WB, IF to detect Septin-2 also known as Neural precursor cell expressed developmentally down-regulated protein 5, septin 2.
merck millipore,默克密理博,07-1813,Anti-Septin-2 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-1813 描述 Anti-Septin-2 Antibody Alternate Names - septin 2
- Neural precursor cell expressed developmentally down-regulated protein 5
- neural precursor cell expressed, developmentally down-regulated 5
背景信息 Septin-2 belongs to the septin family of GTPases. Originally characterized as regulators of cytokinesis, septins were later implicated in other cellular processes. Recent studies show that septins have a broader role in microtubule-dependent processes, such as karyokinesis, exocytosis, and maintenance of cell shape. Many members of the septin family have been shown to colocalize or interact with the microtubule cytoskeleton, suggesting that these might be general properties of septins. Septin-2 is expressed in the brain and may be associated with Alzheimer's disease. 产品信息 格式 Serum 控制 - Hek293 cell lysate
演示 Unpurified rabbit polyclonal with 0.05% sodium azide. 应用 应用 Use Anti-Septin-2 Antibody (Rabbit Polyclonal Antibody) validated in WB, IF to detect Septin-2 also known as Neural precursor cell expressed developmentally down-regulated protein 5, septin 2. 主要应用 - Western Blotting
应用说明 Immunofluorescence: Reported by external laboratory using representative lot. 生物信息 免疫原品种 His-tagged recombinant protein corresponding to human Septin-2. 表位 Unknown 宿主 Rabbit 特异性 This antibody recognizes Septin-2. 品种反应性 RatHumanMouse Species Reactivity Note Proven to react with human, mouse, and rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_004395.1
基因符号 - SEPT2
- DIFF6
- NEDD-5
- NEDD5
- Pnutl3
- hNedd5
纯化方法 Unpurified UniProt编号 - Q15019
UniProt汇总 FUNCTION: Required for normal progress through mitosis. Involved in cytokinesis.
SUBUNIT STRUCTURE: Monomer, and homodimer. Nucleotide binding promotes dimerization. Heterohexamer composed of two heterotrimers containing one copy each of SEPT2, SEPT6 and SEPT7. The asymmetrical heterotrimers associate head-to-head to form a hexameric unit that assembles into filaments.
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm › cytoskeleton › spindle. Note: Accumulates near the contractile ring from anaphase through telophase, and finally condenses into the midbody. In interphase and postmitotic cells, localized to fibrous or granular structures, depending on the growth state of the cell By similarity.
SEQUENCE SIMLARITIES: Belongs to the septin family.产品使用声明 质量保证 Evaluated by Western Blot in Hek293 cell lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Septin-2 on 10 µg of Hek293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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