merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE22,Anti-NO66 Antibody, clone 8A7-G10

  • merck millipore,默克密理博,MABE22,Anti-NO66 Antibody, clone 8A7-G10

    产品名称：Anti-NO66 Antibody, clone 8A7-G10
    产品型号：MABE22
    Use Anti-NO66 Antibody, clone 8A7-G10 (Mouse Monoclonal Antibody) validated in WB to detect NO66 also known as MYC-associated protein with JmjC domain or Nucleolar protein 66.

    merck millipore,默克密理博,MABE22,Anti-NO66 Antibody, clone 8A7-G10

  • 产品介绍
  • merck millipore,默克密理博,MABE22,Anti-NO66 Antibody, clone 8A7-G10

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE22
    描述 Anti-NO66 Antibody, clone 8A7-G10
    Alternate Names
    • Lysine-specific demethylase NO66
    • chromosome 14 open reading frame 169
    • MYC-associated protein with JmjC domain
    • Nucleolar protein 66
    背景信息 NO66 is a lysine-specific demethylase that removes methyl groups from histone H3 at lysine 4 and and lysine 36. This enzyme has been shown to more readily demethylate trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 Lys4 (H3K4me1) consistent with its role in modulating the histone code. This protein is a highly conserved, constitutive nucleolar component that shows a dual localization pattern with strong enrichment in the granular part of nucleoli and in distinct nucleoplasmic entities.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-NO66 Antibody, clone 8A7-G10 (Mouse Monoclonal Antibody) validated in WB to detect NO66 also known as MYC-associated protein with JmjC domain or Nucleolar protein 66.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Recombinant protein corresponding to mouse NO66.
    表位 Unknown
    克隆 8A7-G10
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes NO66.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_076122
    基因符号
    • hsNO66
    • NO66
    纯化方法 Protein G purfied
    UniProt编号
    • Q9JJF3
    UniProt汇总 FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region.

    CATALYTIC ACTIVITY: Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2.

    Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2.

    COFACTOR: Binds 1 Fe2+ ion per subunit.

    SUBUNIT STRUCTURE: Interacts with SP7/OSX; the interaction is direct.

    SUBCELLULAR LOCATION: Nucleus › nucleolus By similarity. Nucleus › nucleoplasm

    TISSUE SPECIFICTY: Present in developing bones (at protein level). Widely but not ubiquitously expressed.

    SEQUENCE SIMILARITIES: Belongs to the MINA53/NO66 family. NO66 subfamily.

    Contains 1 JmjC domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected NO66 on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE22,Anti-NO66 Antibody, clone 8A7-G10

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