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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1450-I Replaces 07-1450 描述 Anti-Beta Pix, SH3 Domain Antibody Alternate Names - p85
- Rho guanine nucleotide exchange factor 7
- Beta-Pix
- COOL-1
- PAK-interacting exchange factor beta
背景信息 Beta-Pix (ARHGEF7, βPix, COOL) is a Rho guanine nucleotide exchange factor (GEF). Beta-Pix is a p21-activated protein kinase (PAK)-interacting exchange factor (Pix, COOL, p85SPR) that has been identified as a putative guanine nucleotide exchange factor (GEF) for Rac/Cdc42. The variants of Beta-Pix isoforms exhibit different tissue distributions. Beta-Pix-a is expressed ubiquitously in all the tissues examined, and other isoforms are expressed mainly in the central nervous system. PAK, a Ser/Thr kinase, is an important mediator of Rho family activity interacts with Beta-Pix at the SH3 domain of Beta-Pix though its proline rich region. This interaction is thought to affect the GTP hydrolysis rate of Rac and Cdc42. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Beta Pix using this Anti-Beta Pix antibody, SH3 Domain validated for use in western blotting. 主要应用 - Western Blotting
应用说明 Western Blotting Analysis: 1 µg/mL from a representative lot detected Beta-Pix, SH3 Domain in 10 µg of PC-12 cell lysate. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the SH3 domain of human Beta-Pix, SH3 Domain. 表位 SH3 domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 RatHumanMouse Species Reactivity Note Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001106983
基因符号 - PIXB
- ARHGEF7
- COOL1
- P85SPR
- PAK3BP
纯化方法 Affinity purified UniProt编号 - Q14155
产品使用声明 质量保证 Evaluated by Western Blotting in Jurkat cell lysate.
Western Blotting Analysis: 0.2 µg/mL of this antibody detected Beta-Pix, SH3 Domain in 10 µg of Jurkat cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,MAB1950Z,Anti-Integrin α2 Antibody, clone P1E6, azide free
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