merck millipore,默克密理愽
  • merck millipore,默克密理博,06-935,Anti-Estrogen Receptor α Antibody

  • merck millipore,默克密理博,06-935,Anti-Estrogen Receptor α Antibody

    产品名称：Anti-Estrogen Receptor α Antibody
    产品型号：06-935
    Anti-Estrogen Receptor α Antibody is a Rabbit Polyclonal Antibody for detection of Estrogen Receptor α also known as Estrogen receptor-like 1, Estrogen-related receptor alpha & has been validated in E More>>

    merck millipore,默克密理博,06-935,Anti-Estrogen Receptor α Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-935,Anti-Estrogen Receptor α Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, H, RICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-935
    描述 Anti-Estrogen Receptor α Antibody
    Alternate Names
    • Nuclear receptor subfamily 3 group A member 1
    • ER-alpha
    • Estradiol receptor
    背景信息 Estrogen Receptor alpha is a 65 kDa protein and a member of the steroid family of nuclear receptors. Estrogen Receptor alpha is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change that allows dimerization and binding to estrogen response element sequences. When bound to DNA, Estrogen Receptor alpha can positively or negatively regulate gene transcription. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Estrogen Receptors play an important role in regulating mammary gland growth and differentiation. Breast tumors that are ER positive may also show a more favorable response to anti-estrogen therapies.
    产品信息
    格式 Affinity Purified
    控制
    • MCF7 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Estrogen Receptor α Antibody is a Rabbit Polyclonal Antibody for detection of Estrogen Receptor α also known as Estrogen receptor-like 1, Estrogen-related receptor alpha & has been validated in EMSA, ICC, IHC, IP & WB.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: 0.2 µg/µL from a representative lot detected Estrogen Receptor a in MCF7 cell lysate.

    Immunocytochemistry Analysis: 2 µg/mL from a representative lot detected Estrogen Receptor a in MCF7 cell lysate.

    Immunohistochemistry Analysis: A 1:400 dilution from a representative lot detected Estrogen Receptor a in human breast cancer and uterine cancer cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of rat Estrogen Receptor alpha.
    表位 C-terminus.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the C-terminus of Estrogen Receptor alpha.
    品种反应性 MouseHumanRat
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Rat based on immunogen design. Predicted to react with Mouse based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_036821
    Entrez基因汇总 Acts as a transcriptional activator when bound to estrogen; may play a role in myocardial regulation.
    基因符号
    • Nr3a1
    • Esr1
    • Esr
    • Estr
    纯化方法 Affinity purified
    UniProt编号
    • P06211
    UniProt汇总 FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Can activate the transcriptional activity of TFF1.

    SUBUNIT STRUCTURE: Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with the NCOA3, NCOA5 and NCOA6 coactivators. Interacts with NCOA7; the interaction is ligand-inducible. Interacts with AKAP13, CUEDC2, HEXIM1, KDM5A, PELP1, PHB2, SLC30A9 and SMARD1. Interacts with MUC1; the interaction is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with MLL2. Interacts with ATAD2; the interaction is enhanced by estradiol. Interacts with KIF18A and LDB1. Interacts with RLIM (via its C-terminus). Interacts with MACROD1. Interacts with FOXL2. Interacts with SH2D4A and PLCG. Interacts with SH2D4A; the interaction blocks binding to PLCG and inhibits estrogen-induced cell proliferation. Interacts with DYNLL1. Interacts with CCDC62; the interaction requires estradiol and appears to enhance the transcription of target genes. Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with PRMT2. Interacts with PIK3R1 or PIK3R2, SRC and PTK2. Interacts with RBFOX2. Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with CITED1; the interaction is estrogen-dependent. Interacts with DYX1C1, MAP1S and UBE1C.

    SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
    产品使用声明
    质量保证 Evaluated by Western Blot in MCF7 cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected Estrogen Receptor a in MCF7 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-935,Anti-Estrogen Receptor α Antibody

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