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  • merck millipore,默克密理博,07-145,Anti-phospho-Histone H3 (Ser28) Antibody

  • merck millipore,默克密理博,07-145,Anti-phospho-Histone H3 (Ser28) Antibody

    产品名称：Anti-phospho-Histone H3 (Ser28) Antibody
    产品型号：07-145
    Use Anti-phospho-Histone H3 (Ser28) Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC, DB, PIA, ChIP to detect phospho-Histone H3 (Ser28) also known as H3F3, H3F3B, H3S28P.

    merck millipore,默克密理博,07-145,Anti-phospho-Histone H3 (Ser28) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-145,Anti-phospho-Histone H3 (Ser28) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HChIP, WB, ICCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-145
    描述 Anti-phospho-Histone H3 (Ser28) Antibody
    Alternate Names
    • H3/g
    • Histone H3.1t
    • H3/t
    • H3t
    背景信息 Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
    产品信息
    格式 Affinity Purified
    控制
    • HeLa acid extract
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-phospho-Histone H3 (Ser28) Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC, DB, PIA, ChIP to detect phospho-Histone H3 (Ser28) also known as H3F3, H3F3B, H3S28P.
    主要应用
    • Chromatin Immunoprecipitation (ChIP)
    • Western Blotting
    • Immunocytochemistry
    应用说明 Western Blot Analysis: A 1:2,000 dilution from a representative lot detected phospho-Histone H3 (Ser28) in 10 µg of untreated and colcemid treated HeLa acid extract.

    Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected phospho-Histone H3 (Ser28) in HeLa cells.

    Chromatin Immunoprecipitation Analysis: A representative lot immunoprecipitated phospho-Histone H3 (Ser28) in colcecmid treated HeLa cell lysate.

    Dot Blot Specificity Analysis: A representative lot of this antibody detected peptides corresponding to phospho-Histone H3 (Ser28), but not peptides corresponding to other unmodified and modifed Histones.

    Peptide Inhibition Analysis: A 1:500 dilution form a representative was blocked by phospho-Histone H3 (Ser28) peptides, but not non-specific peptides.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to Histone H3 phosphorylated at Ser28.
    表位 Histone H3 phosphorylated at Ser28
    宿主 Rabbit
    特异性 This antibody recognizes Histone H3 phosphorylated at Ser28.
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with Human and Mouse. This antibody is expected to demonstrate broad species reactivity due to sequence conservation.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_003484.1
    Entrez基因汇总 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
    基因符号
    • H3FT
    • HIST3H3
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • Q16695
    UniProt汇总 FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

    SUBUNIT STRUCTURE: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    SUBCELLULAR LOCATION: Nucleus. Chromosome.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa acid extract.

    Western Blot Analysis: A 1:2,000 dilution of this antibody detected phospho-Histone H3 (Ser28) in 10 µg of HeLa acid extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-145,Anti-phospho-Histone H3 (Ser28) Antibody

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