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品种反应性 主要应用 宿主 格式 抗体类型 M, H IH(P) Rb Purified Polyclonal Antibody 描述 产品目录编号 07-1407 Replaces AB3140 描述 Anti-GLUT-8 Antibody, CT Alternate Names - solute carrier family 2 (facilitated glucose transporter),<br />member 8
- Glucose transporter type 8
- Glucose transporter type X1
- glucose transporter X1
- solute carrier family 2 (facilitated glucose transporter)<br />member 8
背景信息 GLUT-8 is a glucose transporter facilitated by the regulation of insulin, binding cytochalasin B such that the orientation is glucose-inhibitive. In appearance, the transporter seems to be a dual-specific sugar transporter since fructose can also be inhibitive. GLUT-8 is expressed largely in the testis, where down-regulation is facilitated by estrogen. However, GLUT-8 is not highly expressed in testicular carcinoma. Lower levels of GLUT-8 are present in most other tissues. 产品信息 格式 Purified 控制 - Human kidney tissue.
演示 Liquid in PBS with 0.1% BSA. 应用 应用 Anti-GLUT-8 Antibody, C-terminus detects level of GLUT-8 & has been published & validated for use in IH(P). 主要应用 - Immunohistochemistry (Paraffin)
生物信息 免疫原品种 An 11 amino acid sequence near the C-terminus of mouse Glut-8 (Doege et al. 2000; Carayannopoulos et al. 2000) 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes GLUT-8. 品种反应性 MouseHuman Species Reactivity Note Reacts with human. Expected to react in mouse based on sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - Q9NY64
基因符号 - OTTHUMP00000022176
- GLUT-8
- GLUT8
- GLUTX1
纯化方法 Immunoaffinity purified UniProt编号 - Q9NY64
UniProt汇总 FUNCTION: Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose By similarity.
SUBUNIT STRUCTURE: Interacts with AP2B1 By similarity.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesicle membrane; Multi-pass membrane protein By similarity. Note: Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration By similarity.
TISSUE SPECIFICITY: Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.
INDUCTION: In testis, down-regulated by estrogen.
SEQUENCE SIMILARITIES: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]产品使用声明 质量保证 Evaluated by Immunohistochemistry in human kidney tissue
Immunohistochemistry Analysis: 1:100 dilution of this lot detected GLUT-8 in human kidney tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µg
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