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品种反应性 主要应用 宿主 格式 抗体类型 B, H, M, R, Ch, Ca WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-1378 商名 - Upstate
描述 Anti-QIK (SIK2) Antibody Alternate Names - salt-inducible serine/threonine kinase 2
- Qin-induced kinase
- SNF1-like kinase 2
- Salt-inducible protein kinase 2
- salt-inducible kinase 2
背景信息 QIK (Qin-induced Kinase, SNF1LK2, SIK2, Salt-induced protein Kinase 2) is a Ser/Thr kinase that belongs to the AMPK/SNF1 kinase family. QIK is phosphorylated and activated by the tumor suppressor LKB1 when in complex with the pseudokinase STRAD and the scaffolding protein MO25. QIK has been found in adipocytes where it is known to phosphorylate a few substrates that include insulin receptor substrate 1 (IRS1) on Ser794 and TORC2 (also known as CRTC2 and not to be confused with the mTOR complex) on Ser171. The phosphorylation of TORC2 results in its translocation to the nucleus where it binds to CREB. 产品信息 格式 Purified 控制 - HeLa Cell Lysate
演示 Protein A purified rabbit serum in 0.1M Tris-Glycine (pH7.4) 15mM NaCl, and 0.05% NaN3 with 30% glycerol. 应用 应用 Anti-QIK (SIK2) Antibody is an antibody against QIK (SIK2) for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to the C-term of human QIK. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Detects QIK 品种反应性 BovineHumanMouseRatChickenCanine Species Reactivity Note Human. Close homology with mouse, rat, chicken, dog, and cow. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_056006
基因符号 - SIK2
- DKFZp434K1115
- EC 2.7.11
- KIAA0781
- LOH11CR1I
- QIK
- SIK-2
纯化方法 Protein A purfied UniProt编号 - Q9H0K1
UniProt汇总 FUNCTION: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium.
ENZYME REGULATION: Activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.
SUBUNIT: Interacts with and phosphorylates TORC2/CRTC2.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).产品使用声明 质量保证 Western Blot Analysis:
This lot detected QIK at 1:1,000-1:2,000 dilution in HeLa lysates via SDS-PAGE and transferred to PVDF (Immobilon-P).使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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