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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABF200 Replaces MABF201 描述 Anti-Bst2 Antibody Alternate Names - HM1.24 antigen
- Bone marrow stromal cell antigen 2
- BST-2
- CD317
背景信息 Bone marrow stromal cell antigen 2 (BST-2, Bst2), also known as CD317, and HM1.24 antigen, is an IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian viruses by directly tethering nascent virions to the membranes of infected cells. Bst2 has been shown to interact with various viruses, including: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Bst2 may inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Additionally, it is implied to interact with LILRA4/ILT7, which results in providing negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. This activity suggests that Bst2 can provide a potential therapeutic strategy for the treatment of HIV/AIDS. Bst2 may play a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells 产品信息 格式 Affinity Purified 控制 - Human placenta tissue
演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Detect Bone marrow stromal antigen 2 using this rabbit polyclonal antibody, Anti-Bst2 Antibody validated for use in western blotting. 主要应用 - Western Blotting
应用说明 Western Blotting Analysis: 2 µg/mL from a representative lot detected Bst2 in 15 µg of Daudi cell lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the N-terminus of mouse Bst2. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the N-terminus of Bst2. 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - BST2
- Bst2
- BST-2
纯化方法 Antigen Affinity purified UniProt编号 - Q8R2Q8
产品使用声明 质量保证 Evaluated by Immunohistochemistry in human placenta tissue.
Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Bst2 in human placenta tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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