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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 06-918 品牌系列 Upstate
商名 - Upstate
描述 Anti-Rsk2/MAPKAP Kinase 1b Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect Rsk2/MAPKAP Kinase 1b using this Anti-Rsk2/MAPKAP Kinase 1b Antibody validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide (C-NRNQSPVLEPVGRS) corresponding to amino acids 711-724 of mouse Rsk2 宿主 Rabbit 特异性 Rsk2/MAPKAP K1β 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_004577.1
Entrez基因汇总 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). 基因符号 - ISPK-1
- RPS6KA3
- CLS
- RSK-2
- RSK2
- p90-RSK2
- ISPK1
- MRX19
- HU-3
- pp90RSK2
- MAPKAPK1B
- HU-2
- RSK
- S6K-alpha3
纯化方法 Protein A chromatography UniProt编号 - P51812
UniProt汇总 FUNCTION: SwissProt: P51812 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
COFACTOR: Magnesium (By similarity).
SIZE: 740 amino acids; 83736 Da
SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
TISSUE SPECIFICITY: Expressed in many tissues, highest levels in skeletal muscle.
PTM: Autophosphorylated on Ser-386, as part of the activation process (By similarity). & Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369 (By similarity).
DISEASE: SwissProt: P51812 # Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.
SIMILARITY: SwissProt: P51812 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.产品使用声明 质量保证 routinely evaluated by immunoblot on mouse 3T3 cell lysate 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 100 µg
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