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merck millipore,默克密理博,475856,Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem
产品名称：Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem
产品型号：475856
The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.
merck millipore,默克密理博,475856,Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,475856,Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem
重要规格表
经验配方 CAS号 C₁₅H₁₀Cl₂N₂O₂S 338967-87-6 描述 概述 A cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC50 = 10 and 50 µM in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50 < 10 µM) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- (Cat. Nos. 569396 and 569397) as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release. 产品目录编号 475856 品牌系列 Calbiochem®
同义词 Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor, 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one 参考 参考 Cassidy-Stone A., et al. 2008. Dev. Cell 14, 193. 产品信息 CAS号 338967-87-6 形式 White solid Hill配方 C₁₅H₁₀Cl₂N₂O₂S 化学配方 C₁₅H₁₀Cl₂N₂O₂S Molar Mass 353.2 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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