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品种反应性 主要应用 宿主 格式 抗体类型 M, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-868 品牌系列 Upstate
商名 - Upstate
描述 Anti-GABAA Receptor α1 Antibody Alternate Names - gamma-aminobutyric acid A receptor, alpha 1
- Gamma-Amino Butyric Acid Receptor Subunit Alpha-1
- Gaba(A) Receptor Subunit Alpha-1
- GABA(A) receptor subunit alpha-1
- gamma-aminobutyric acid (GABA) A receptor, alpha 1
背景信息 The neurotransmitter GABA (gamma-aminobutyric acid) binds to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neurons. Three general classes of GABA receptors are known: GABAA and GABAC (ionotropic) receptors and GABAB (metabotropic) receptors. The GABAA (gamma-Aminobutyric Acid type A) receptor is a multiprotein complex that acts as a ligand-gated chloride channel. These receptors are hetero-oligomers, for which 6 subunits are currently known (a, b, g, d, e and r). There are at least 6 different isoforms of the alpha subunit, and receptor subunit expression varies during development. Increased alpha1 subunit assembly in postsynaptic receptors of cerebellar inhibitory synapses is responsible for the fast inhibitory synaptic currents observed during postnatal development. Additionally, alpha1-containing GABAA receptors are important in regulating the reinforcing properties of alcohol, and expression of the alpha1 subunit increases upon chronic exposure to alcohol, making it a potential therapeutic target for alcohol dependency. 产品信息 格式 Affinity Purified 控制 - Rat Brain Microsomal Preparation Tissue Lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-GABAA Receptor α1 Antibody is validated for use in IH, IP, WB for the detection of GABAA Receptor α1. 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected GABAA Receptor α1 in rat hippocampus tissue.
Immunoprecipitation Analysis: 5 µL from a representative lot immunoprecipitated GABAA Receptor α1 in rat brain microsomal preparation RIPA lysate.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the topological domain of rat GABAA Receptor α1. 表位 Topological domain. 宿主 Rabbit 特异性 This antibody recognizes the topographical domain of GABAA Receptor α1. 品种反应性 MouseRat Species Reactivity Note Demonstrated to react with Rat and Mouse. Other homologies: Human (94% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - Np_899155
Entrez基因汇总 Subunit of GABAA receptors, which bind benzodiazepines and act as inhibitory ion channels in the brain. 基因符号 - EJM
- Gabra1
- Gabra-1
- GABA
纯化方法 Affinity purified UniProt编号 - P62813
UniProt汇总 FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
SUBUNIT STRUCTURE: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with TRAK1.
SUBCELLULAR LOCATION: Cell junction > synapse > postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.产品使用声明 质量保证 Evaluated by Western Blot in rat brain microsomal preparation tissue lysate.
Western Blot Analysis: A 1:10,000 dilution of this antibody detected GABAA Receptor α1 in 10 µg of rat brain microsomal preparation tissue lysate.储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µL
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