merck millipore,默克密理愽
  • merck millipore,默克密理博,06-867,Anti-phospho-STAT5A/B (Ser726/Ser731) Antibody

  • merck millipore,默克密理博,06-867,Anti-phospho-STAT5A/B (Ser726/Ser731) Antibody

    产品名称：Anti-phospho-STAT5A/B (Ser726/Ser731) Antibody
    产品型号：06-867
    Anti-phospho-STAT5A/B (Ser726/Ser731) Antibody is a rabbit polyclonal antibody for detection of phospho-STAT5A/B (Ser726/Ser731) also known as signal transducer & activator of transcription 5A/B & has More>>

    merck millipore,默克密理博,06-867,Anti-phospho-STAT5A/B (Ser726/Ser731) Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-867,Anti-phospho-STAT5A/B (Ser726/Ser731) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbSerumPolyclonal Antibody
    描述
    产品目录编号 06-867
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-STAT5A/B (Ser726/Ser731) Antibody
    产品信息
    格式 Serum
    演示 rabbit antiserum in 30% glycerol and 0.05% sodium azide
    应用
    应用 Anti-phospho-STAT5A/B (Ser726/Ser731) Antibody is a rabbit polyclonal antibody for detection of phospho-STAT5A/B (Ser726/Ser731) also known as signal transducer & activator of transcription 5A/B & has been tested in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide (DQAP[pS]PAVC) corresponding to amino acids 722-730 of human STAT5A or 727-735 of human STAT5B
    宿主 Rabbit
    特异性 phosphorylated STAT5A (S726) and STAT5B (S731), does not recognize STAT5B containing a S731A mutation
    同种型 IgG
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_003152.2
    Entrez基因汇总 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
    基因符号
    • STAT5
    • STAT5A
    • MGF
    修改
    • Phosphorylation
    纯化方法 Antiserum
    UniProt编号
    • P42229
    UniProt汇总 FUNCTION: SwissProt: P42229 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
    SIZE: 794 amino acids; 90647 Da
    SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
    PTM: Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL- 15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA- binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).
    SIMILARITY: SwissProt: P42229 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
    产品使用声明
    质量保证 routinely evaluated by immunoprecipitating STAT5A from RIPA lysates of Nb2-Sp cells that had been treated with prolactin; subsequent immunoblotting was performed using Anti-STAT5A (Catalog #06-968)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µL

    merck millipore,默克密理博,06-867,Anti-phospho-STAT5A/B (Ser726/Ser731) Antibody

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