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merck millipore,默克密理博,HTS137RTA,Ready-to-Assay™ CaS Calcium Sensor Receptor Frozen Cells
产品名称：Ready-to-Assay™ CaS Calcium Sensor Receptor Frozen Cells
产品型号：HTS137RTA
Human CaS GPCR frozen cells for Calcium Flux FLIPR Assays.
merck millipore,默克密理博,HTS137RTA,Ready-to-Assay™ CaS Calcium Sensor Receptor Frozen Cells
- 产品介绍
重要规格表
应用说明 品种 宿主细胞 蛋白靶 Calcium Flux Assays Human Chem-1 CaS 描述 产品目录编号 HTS137RTA 商名 - Ready-to-Assay
描述 Ready-to-Assay™ CaS Calcium Sensor Receptor Frozen Cells 背景信息 Millipore’s Ready-to-Assay GPCR frozen cells are designed for simple, rapid calcium assays with no requirement for intensive cell culturing. Millipore has optimized the freezing conditions to provide cells with high viability and functionality post-thaw. The user simply thaws the cells and resuspends them in media, dispenses cell suspension into assay plates and, following over night recovery, assays for calcium response.
Calcium homeostasis in vertebrates is regulated by hormonal communication between the parathyroid and thyroid glands, kidney, bone, and intestine. A central mediator of this regulatory system is the calcium sensor CaS (also known as CaR), a class III GPCR that is activated by high concentrations of extracellular calcium and other divalent cations. The cell types that are responsive to variations in blood calcium concentration express CaS and respond to changes in extracellular calcium in a CaS-dependent fashion. Activation of CaS in parathyroid chief cells inhibits PTH release, which results in decreased calcium mobilization from bone. In contrast, stimulation of CaS activity in the C cells of the thyroid increases secretion of calcitonin, which causes decreased bone resorption and increased urinary excretion of calcium. Allosteric "calcimimetic" potentiators are being evaluated for treatment of primary hyperparathyroidism (Brown and MacLeod, 2001). Millipore’s cloned human CaS-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CaS expression on the cell surface for functional detection via the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists, antagonists and modulators at CaS Receptor.产品信息 部件 - Fifty (50) mL of Media Component.
- Pack contains 2 vials of mycoplasma-free cells, 1 ml per vial.
检测方法 Fluorescent 应用 应用 Human CaS GPCR frozen cells for Calcium Flux FLIPR Assays. 应用说明 Calcium Flux Assays 生物信息 品种 Human Entrez基因编号 - NM_000388
GPCR类别 C 宿主细胞 Chem-1 蛋白靶 CaS 靶子系列 Calcium sensor 细胞系类型 - Ready-to-Assay
产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
- This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck-Millipore to request certain information about you and the establishment where the GMOs are being handled.
包装信息 数量 1 kit
上一件merck millipore产品：merck millipore,默克密理博,567422,Sodium Acetate, 3M, pH 5.2, Molecular Biology Grade - CAS 127-09-3 - Calbiochem
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