merck millipore,默克密理愽
  • merck millipore,默克密理博,06-820,Anti-phospho-Adducin (Ser662) Antibody

  • merck millipore,默克密理博,06-820,Anti-phospho-Adducin (Ser662) Antibody

    产品名称：Anti-phospho-Adducin (Ser662) Antibody
    产品型号：06-820
    This Anti-phospho-Adducin (Ser662) Antibody is validated for use in WB for the detection of phospho-Adducin (Ser662).

    merck millipore,默克密理博,06-820,Anti-phospho-Adducin (Ser662) Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-820,Anti-phospho-Adducin (Ser662) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, Ca, H, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-820
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-Adducin (Ser662) Antibody
    产品信息
    格式 Affinity Purified
    演示 0.014 M phosphate buffer, pH 7.6, 0.175 M NaCl, 0.07% sodium azide, and 30% glycerol. Liquid at -20°C.
    应用
    应用 This Anti-phospho-Adducin (Ser662) Antibody is validated for use in WB for the detection of phospho-Adducin (Ser662).
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide (C-KKFRTPpSFLKKNK) corresponding to amino acids 656-668 of human gamma-Adducin
    宿主 Rabbit
    特异性 phosphorylated serine 662 of γ-Adducin, phosphorylated serine 724 of α-Adducin, phosphorylated serine 713 of β-Adducin
    同种型 IgG
    品种反应性 RatCanineHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_016824
    Entrez基因汇总 Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known.
    基因符号
    • Gamma-adducin
    • ADD3
    • adducin-like
    • ADDL
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • Q9UEY8
    UniProt汇总 FUNCTION: SwissProt: Q9UEY8 # Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
    SIZE: 706 amino acids; 79155 Da
    SUBUNIT: Heterodimer of an alpha and a gamma subunit.
    TISSUE SPECIFICITY: Heart only expresses isoform 1.
    DOMAIN:SwissProt: Q9UEY8 Comprised of three regions: a N-terminal protease- resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
    PTM: Sumoylated.
    SIMILARITY: Belongs to the aldolase class II family. Adducin subfamily.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from 3T3/NIH cells or on canine MDCK cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-820,Anti-phospho-Adducin (Ser662) Antibody

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