merck millipore,默克密理愽
  • merck millipore,默克密理博,06-725-I,Anti-FcεRI α subunit Antibody

  • merck millipore,默克密理博,06-725-I,Anti-FcεRI α subunit Antibody

    产品名称：Anti-FcεRI α subunit Antibody
    产品型号：06-725-I
    Detect FcεRI α subunit using this Anti-FcεRI α subunit Antibody validated for use in Western Blotting, Immunoprecipitation, ICC.

    merck millipore,默克密理博,06-725-I,Anti-FcεRI α subunit Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-725-I,Anti-FcεRI α subunit Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBRbSerumPolyclonal Antibody
    描述
    产品目录编号 06-725-I
    Replaces 06-725
    描述 Anti-FcεRI α subunit Antibody
    Alternate Names
    • IgE Fc receptor subunit alpha
    • High affinity immunoglobulin epsilon receptor subunit alpha
    • Fc-epsilon RI-alpha
    • FcERI
    背景信息 The allergic reaction is mediated through the IgE high affinity receptor (FcεRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FcεRI receptor complexes causes the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for the allergic reaction. The FcεRI receptor is a tetrameric complex, consisting of an a-chain, b-chain and a dimeric g-chain. The a-chain is primarily involved with the binding of IgE, but the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FcεRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors.
    产品信息
    格式 Serum
    控制
    • RBL cell lysate
    演示 Rabbit polyclonal serum containing 0.05% sodium azide.
    应用
    应用 Detect FcεRI α subunit using this Anti-FcεRI α subunit Antibody validated for use in Western Blotting, Immunoprecipitation, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Western Blot Analysis: A 1:5,000 dilution from a representative lot detected FcεRI α subunit in 10 µg of human spleen tissue lysate.

    Immunoprecipitation Analysis: A 1:50 dilution from a representative lot immunoprecipitated FcεRI α subunit from human spleen whole lysate.

    Flow Cytometry Analysis: A 1:200 dilution from a representative lot detected FcεRI α subunit in RBL cells.
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to the extracellular domain of human FcεRI α subunit.
    表位 Extracellular domain
    宿主 Rabbit
    特异性 This antibody recognizes the extracellular domain of FcεRI α subunit.
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001992
    基因符号
    • FCE1A
    • FCER1A
    纯化方法 Unpurified
    UniProt编号
    • P12319
    产品使用声明
    质量保证 Evaluated by Western Blot in RBL cell lysate.

    Western Blot Analysis: A 1:5,000 dilution of this antibody detected FcεRI α subunit in 10 µg of RBL cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,06-725-I,Anti-FcεRI α subunit Antibody

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